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IRCT20200907048643N1 IRCT 2020-09-14 Oroumia University of Medical Sciences Comparison of three-drug and consecutive treatment regimens in the eradication of Helicobacter pylori in patients referred to the gastrointestinal clinic of Imam Khomeini Hospital in Urmia Comparison of three-drug and consecutive treatment regimens in the eradication of Helicobacter pylori in patients referred to the gastrointestinal clinic of Imam Khomeini Hospital in Urmia 2018-03-21 anticipated 270 Complete https://irct.ir/trial/50770 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Diagnostic, Randomization description: Gastrointestinal patients were selected after entering the gastrointestinal clinic and were randomly divided into three groups. A total of 270 patients were selected in groups of 90 with three, The groups were divided into each of which was randomly given one of the drug groups.The tool for making random blocks was https://www.sealedenvelope.com. N/A Comparison of three-drug and consecutive treatment regimens in eradication of Helicobacter pylori in patients referred to the gastrointestinal clinic of Imam Khomeini Hospital in Urmia. Intervention 1: Intervention group: First group: omeprazole 20mg twice daily + amoxicillin one gram twice daily + clarithromycin 500mg twice daily for 10 days Second group: omeprazole 20mg twice daily + amoxicillin one gram daily for 2 weeks + levofloxacin 500mg Twice a day in the first week of the diet and the third group: omeprazole 20mg twice daily + amoxicillin one gram twice daily for 5 days + metronidazole 500mg twice daily for the second 5 days + clarithromycin 500mg twice daily for 5 second day. Intervention 2: Intervention group: Group 2: omeprazole 20mg twice daily + amoxicillin 1 g daily for 2 weeks + levofloxacin 500mg twice daily in the first week of the diet. Intervention 3: Intervention group: Group 3: omeprazole 20mg twice daily + amoxicillin one gram twice daily for 5 days + metronidazole 500mg twice daily for the second 5 days + clarithromycin 500mg twice daily for the second 5 days. Yes - There is a plan to make this available What will be shared: It is about the best treatment. When: Always To whom: Researcher Conditions: Always Where to obtain: Patients referred to the gastrointestinal clinic How to obtain: It does not have a specific process Comments:
public Hamid Reza Mehryar
Streat Resalt
Urima Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 omid.garkaz23@gmail.com Oroumia University of Medical Sciences scientific Hamid Reza Mehryar
Resalt Streat
Urima Iran (Islamic Republic of) 5714783734 +98 44 3223 4897 Hamidrezamehryar2010@gmail.com Oroumia University of Medical Sciences Iran (Islamic Republic of) 1- Endoscopic primary infection of Helicobacter pylori 2-Have symptoms of dyspepsia for at least 6 months or more 3- No history of taking any antibiotics during the last month and no history of taking proton and antacid pump inhibitors in the last month 18 years no limit Both 1- Endoscopic primary infection of Helicobacter pylori 2-Have symptoms of dyspepsia for at least 6 months or more 3- No history of taking any antibiotics during the last month and no history of taking proton and antacid pump inhibitors in the last month K20 Oesophagitis Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group: First group: omeprazole 20mg twice daily + amoxicillin one gram twice daily + clarithromycin 500mg twice daily for 10 days Second group: omeprazole 20mg twice daily + amoxicillin one gram daily for 2 weeks + levofloxacin 500mg Twice a day in the first week of the diet and the third group: omeprazole 20mg twice daily + amoxicillin one gram twice daily for 5 days + metronidazole 500mg twice daily for the second 5 days + clarithromycin 500mg twice daily for 5 second day Intervention group: Group 2: omeprazole 20mg twice daily + amoxicillin 1 g daily for 2 weeks + levofloxacin 500mg twice daily in the first week of the diet Intervention group: Group 3: omeprazole 20mg twice daily + amoxicillin one gram twice daily for 5 days + metronidazole 500mg twice daily for the second 5 days + clarithromycin 500mg twice daily for the second 5 days Helicobacter pylori treatment. Timepoint: Patients were referred to the clinic 2 weeks, 6 weeks and 10 weeks after starting treatment. Patients were examined for Helicobacter pylori by Stool Ag test. Individuals who were registered for successful negative test treatment for H. pylori eradication. In the second week visit, all side effects including (bad taste, dry mouth, diarrhea, confusion, tongue burn, nausea and vomiting, abdominal pain, constipation and headache) and patient compliance were recorded based on the number of pills remaining and then four weeks PPI only It was taken and then they did not take any PPI and antibiotics for 4 weeks and then it was proved by Stool Ag eradication of Helicobacter pylori infection in each group. Method of measurement: Blood and stool tests. Oroumia University of Medical Sciences Approved 2018-10-03 Urmia University of Medical Sciences Resalat Street, next to the provincial emergency room Urima West Azarbaijan Iran (Islamic Republic of)