]>
IRCT20200824048500N1 IRCT 2021-01-25 Semnan University of Medical Sciences Effects of Dexmedetomidine and Propofol in brain injury patients A comparison on effectiveness of Dexmedetomidine and Propofol on serum level of NSE and S100B in patients with traumatic brain injury 2021-02-19 anticipated 60 Complete https://irct.ir/trial/50764 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Participants will be randomly assigned to two groups of intervention and control with 30 members using block randomization with block sizes of 2. Randomized permutation blocks (block 2). Excel software rand function was used for randomization, Blinding description: Participants and researchers or outcome assessors are unaware of the allocation of study groups. 2 Traumatic brain patients. Intervention 1: Intervention group 1: Will receive dexmedetomidine 1 mcg/kg IV for intubation.(precedex , Hospira , US). Intervention 2: Intervention group 2 : Will receive propofol (diprivan , Fresenius Kabi , Germany) 5 mcg/kg IV for intubation. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information
public Fateme Feizi
No 75, 5th Street, Sepah Avenue, Varamin
Varamin Iran (Islamic Republic of) 35147-99442 +98 21 3624 0902 fatemefeizi9775@gmail.com Semnan University of Medical Sciences scientific Fateme Feizi
No 75,fifth street ,Sepah Ave,Varamin, Tehran
Varamin Iran (Islamic Republic of) 35147-99442 +98 21 3624 0902 fatemefeizi9775@gmail.com Semnan University of Medical Sciences Iran (Islamic Republic of) Traumatic Brain Injury patients (TBI) Intubation In ICU Over 18 years old 18 years no limit Both Massive bleeding Acute or chronic renal failure Acute or active liver disease Rheumatologic disorders or auto-immune disease Acute MI Hypersensitivity to drugs or egg and Soya S06.2 Diffuse traumatic brain injury Treatment - Drugs Treatment - Drugs Intervention group 1: Will receive dexmedetomidine 1 mcg/kg IV for intubation.(precedex , Hospira , US) Intervention group 2 : Will receive propofol (diprivan , Fresenius Kabi , Germany) 5 mcg/kg IV for intubation. Neuron Specific Enolase (NSE). Timepoint: Before intervention and 24hr after intervention. Method of measurement: Elisa. S100 calcium-binding protein B (S100B). Timepoint: Before intervention and 24hr after intervention. Method of measurement: Elisa. Semnan University of Medical Sciences Approved 2020-07-28 Ethics committee of Semnan University of Medical Sciences Basij Blvd , Semnan University of Medical Sciences Semnan Semnan Iran (Islamic Republic of)