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IRCT201111074731N9 IRCT 2012-03-03 Research vice-chancellor of Tabriz University of Medical Sciences The effect of thoracic epidural combined with total intravenous anesthesia on dose requirement for induction of anesthesia & bis pectoral index The effect of low thoracic epidural anesthesia combined with total intravenous anesthesia on dose requirement for induction and monitoring of depth of anesthesia guided by bispectoral index in patients under upper abdomen surgeries: randomized clinical trial 2011-08-23 anticipated 40 Complete https://irct.ir/trial/5050 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Other. N/A Condition 1: BIS changes due to thoracic epidural anesthesia. Condition 2: anesthesia drug dose changes due to thoracic epidural. Intervention 1: Intervention group: after epidural catheter insertion marcaine 0.25%,0.7ml/m/seg for 10 segments will be adminstered. Intervention 2: Control group: after epidural catheter insertion ,normal saline with same volume of marcaine will be adminstered.
public Hamzeh Hosseinzadeh
Golgasht
Tabriz Iran (Islamic Republic of) 00894113855002 hamzeh1338@yahoo.com Tabriz University of Medical Sciences scientific Hamzeh Hosseinzadeh
Golgasht
Tabriz Iran (Islamic Republic of) +98 41 1385 5002 hamze1338@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Inclusion criteria: Adult patients, belonging to ASA 1&2 class; undergoing elective upper abdomen surgeries. Exclusion criteria: vertebral abnormality; neurologic disorders; cardio vascular diseases; Hgb <12; renal or hepatic failure; chest trauma; Allergy to local anesthetics; Plt <100000; Coagulopathy, βblockers. 18 years 149 years Both T66 -T78 T66 - T78 Other and unspecified effects of external causes Other and unspecified effects of external causes Other Placebo Intervention group: after epidural catheter insertion marcaine 0.25%,0.7ml/m/seg for 10 segments will be adminstered Control group: after epidural catheter insertion ,normal saline with same volume of marcaine will be adminstered Oxygen Saturation. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: pulse oxymetry devices. Mean arterial blood pressure. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: with automatic cuff. BIS. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: BIS devices. Propofol dose for induction & maintenance of anesthesia. Timepoint: Afer intubation, after extubation. Method of measurement: Infusion pump. Heart rate. Timepoint: before epidural, after epidural, before pre med, 3min after pre med, pre induction, post induction, after intubation, each 5min after surgery. Method of measurement: continuous ECG monitoring. Research vice-chancellor of Tabriz University of Medical Sciences Approved 2011-06-28 Research vice-chancellor of Tabriz university of medical sciences Tabriz university of medical sciences, Golgasht Tabriz Iran (Islamic Republic of)