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IRCT20200821048470N1 IRCT 2020-10-12 Ahvaz University of Medical Sciences "Effect of Nebulized Heparin in Patients with Pneumonia" Effect of Daily Administration of Nebulized Heparin on Prevention of Endotracheal Tube Blockage by Clot and Mucus Plug Compared to Normal Saline in Patients with Pneumonia 2020-10-06 anticipated 40 Complete https://irct.ir/trial/50458 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Out of 40 Patients who Entered the Study by Random Block Method,Individuals are Randomly Assigned to Both Interventional and Non-interventional Groups (with placebo).Randomized numbers from 1 to 40 was produced with a calculator, the first twenty numbers allocated to intervention group and the other twenty numbers allocated to control group, Blinding description: Once the patients in the study groups have been identified, the drug and placebo are placed in the same syringes as they are in appearance, and thus patients will not be informed of the contents inside it. 2 Pneumonia. Intervention 1: Intervention group: in this group, patients receive 5,000 units of heparin ampoules per 1 ml mixed with 4 cc of 0.9% normal saline every 6 hours as a nebulization through a tracheal tube. This is done daily for up to 14 days or until the patient becomes extubate or dies. Intervention 2: Control group: in this group, patients after randomization, receive 5 cc of normal saline 0.9% through endotracheal tube nebulization every 6 hours. Yes - There is a plan to make this available What will be shared: Demographic Data and the Result of Clinical Trial When: access begins one year after the results are published To whom: Researchers working in academic and scientific institutions Conditions: Research on related issues Where to obtain: Houshmand Hosseininezhad How to obtain: Communicate with the responsible person via Email Comments:
public Hooshmand Hosseininezhad
Imam Khomeini Hospital., Azadegan Ave
Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 3221 5574 hosseininezhad.h@ajums.ac.ir Ahvaz University of Medical Sciences scientific Seyed Hamid Borsi
Imam Khomeini Hospital., Azadegan Ave
Ahvaz Iran (Islamic Republic of) 6193673166 +98 61 3221 5574 borsi-h@ajums.ac.ir Ahvaz University of Medical Sciences Iran (Islamic Republic of) Patients with pneumonia who have been intubated and admitted to the ICU. All patients have an apache score less than 25. 18 years no limit Both Thrombocytopenia or a history of heparin-induced thrombocytopenia Coagulation disorder with INR above 1.5 pregnant women Any active bleeding and history of intracranial hemorrhage during the last 3 months Patients receiving anticoagulants J95.851 Ventilator associated pneumonia Treatment - Drugs Treatment - Drugs Intervention group: in this group, patients receive 5,000 units of heparin ampoules per 1 ml mixed with 4 cc of 0.9% normal saline every 6 hours as a nebulization through a tracheal tube. This is done daily for up to 14 days or until the patient becomes extubate or dies. Control group: in this group, patients after randomization, receive 5 cc of normal saline 0.9% through endotracheal tube nebulization every 6 hours. The degree of obstruction of the endotracheal tube by plug or bare mucus. Timepoint: On admission and daily. Method of measurement: Clinical Information Collection Form. Hypoxia. Timepoint: On admission and daily. Method of measurement: Drop in arterial blood oxygen saturation to less than 90 or more than 4% of basal level after elimination of other common causes. Infection. Timepoint: On admission and daily. Method of measurement: New VAP event based on different clinic or graph with primary lung infection. Ahvaz University of Medical Sciences Approved 2020-02-19 Ethics committee of Ahvaz Jundishapur University of Medical Sciences Jundishapur University of Medical Sciences, Golestan Blvd., Golestan Town Ahvaz Khouzestan Iran (Islamic Republic of)