IRCT20160307026950N25 IRCT 2020-09-20 Esfahan University of Medical Sciences Effect of Dexamethasone on Nausea and Vomitting after cholecystectomy Comparison of the efficacy of Intraperitoneal Dexamethasone with intravenous Dexamethasone on Nausea and Vomiting after Laparoscopic Cholecystectomy 2020-09-22 anticipated 81 Complete https://irct.ir/trial/50286 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Other design features: In this study, for the first time, we used Intrapritoneal Dexamethasone in laparoscopic cholecystectomy, Randomization description: Randomization will be done simply in which patients will enter into groups A, B, and C respectively, according to their time of admission, then the next three patients will enter into these groups in the same way to complete of number of patients in each three groups, Blinding description: Drugs and Placebo are prepared and coded in the same appearance. The patient, the injecting specialist, the surgeon, and the respondent are unaware of the contents of the injected drug and are blind. 3 Laparoscopic Cholecystectomy. Intervention 1: Intervention group A: Patients receive 2cc intrapritoneal Normal saline and 8mg intravenous Dexamethasone in base of Gallbladder after removing last clamp and exiting laparoscope. Intervention 2: Intervention group B: Patients receive 2cc intravenous Normal saline and 8mg intrapritoneal Dexamethasone in base of Gallbladder after removing last clamp and exiting laparoscope. Intervention 3: Control group: Patients receive 2cc intravenous Normal saline and 2cc intrapritoneal Normal saline in base of Gallbladder after removing last clamp and exiting laparoscope. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information.