IRCT201009054697N1 IRCT 2010-12-07 School of Dentistry, Islamic Azad University Khorasgan Branch Effect of Ketamine on Postendodontic Pain Effect of Preoperative Oral Ketamine in Comparison with Ibuprofen on Postoperative Endodontic Pain 2010-12-11 anticipated 51 Complete https://irct.ir/trial/5028 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention. 3 Postoperative Endodontic Pain. Intervention 1: Oral suspension of ibuprofen, 600 mg, A single dose, 30 minutes before the initiation of treatment, Oral. Intervention 2: Placebo, A single dose, 30 minutes before the initiation of treatment, Oral. Intervention 3: Ketamine hydrochloride, 0.5mg/kg, A single dose, 30 minutes before the initiation of treatment, Oral.

public Ashkan Vakilzadeh

Hezarjerib Avenue, Isfahan and University Blvd, Arqavanieh, Jey Street, Isfahan

Isfahan Iran (Islamic Republic of) +98 21 2621 4610 ashkanvakilzadeh@gmail.com School of Dentistry, Isfahan University of Medical Sciences and School of Dentistry, Islamic Aza Iran (Islamic Republic of) Inclusion criteria: 1. Patient elects root canal therapy for pain originating from a first or second mandibular molar. 2. The diagnosis of irreversible pulpitis is confirmed by a chief complaint of spontaneous pain and cold test application causing an elevated and lingering pain response. 3. The patient presented with American Society of Anesthesiologists (ASA) I or II medical history. 4. Patient reads and understands questionnaires. 5. Patient reports spontaneous pain above 3cm on a VAS (0-10 cm) in past 24h. 6. Patient provides informed consent. Exclusion criteria: 1. Younger than 18 yr or older than 65 yr. 2. Analgesic taken within the last 8h. 3. History of allergy to NSAIDs, ketamine or local anesthetics. 4. Current use of drugs contraindicated with NSAIDs or ketamine. 5. History of gastrointestinal (GI) disorders, renal or hepatic disease, hemorrhagic disorders, active asthma, poorly controlled diabetes mellitus, cardiovascular disease, increased ICP, intracranial mass lesions, ophthalmologic disorder or psychiatric disease. 6. The patient is pregnant or nursing. 7. Periradicular pathosis, other than a widened periodontal ligament. 8. No vital coronal pulp tissue on access. 9. Occurrence of any mistake during root canal therapy. 18 years 65 years Both K08.8, K04 Other specified disorders of teeth and supporting structures - Toothache NOS and Pulpitis: acute Prevention Placebo Prevention Oral suspension of ibuprofen, 600 mg, A single dose, 30 minutes before the initiation of treatment, Oral Placebo, A single dose, 30 minutes before the initiation of treatment, Oral Ketamine hydrochloride, 0.5mg/kg, A single dose, 30 minutes before the initiation of treatment, Oral Pain intensity. Timepoint: Before and at 2, 4, 8, 12 and 24h after treatment. Method of measurement: Visual Analog Scale. The need for additional medication. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire. Time to first request for rescue analgesic. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire. The number of rescue analgesic tablets taken. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire. The incidence of side effects. Timepoint: Until 24h after treatment. Method of measurement: Questionnaire. School of Dentistry, Islamic Azad University Khorasgan Branch Approved 2007-10-24 School of Dentistry, Islamic Azad University Khorasgan Branch University Blvd, Arqavanieh, Jey Street, Isfahan Isfahan Iran (Islamic Republic of)