IRCT20181121041713N3 IRCT 2020-10-06 Shiraz University of Medical Sciences Effect of Bromelain and Turmeric on orthodontic pain Evaluation of the the efficacy of bromelain and turmeric on pain after orthodontic separator placement: A single center, triple blind, randomized clinical trial 2020-11-20 anticipated 135 Complete https://irct.ir/trial/50106 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization method will be used with block length = 9, using online software RANDOM.ORG to allocate patients to three experimental groups with a 1:1:1 ratio, Blinding description: In each groups all tablets will be covered by identical gelatin cover, so the investigators, the patients and the statistician will be all blind to the treatment groups. 3 Evaluation of pain intensity after separator placement in orthodontics patients.. Intervention 1: Intervention group: 200 mg Bromelain. Intervention 2: Intervention group: 150 mg Bromelain + 300 mg Turmeric. Intervention 3: Control group: 400 mg Ibuprofen. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is not applicable