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IRCT20200731048258N1 IRCT 2020-10-22 Bagheiat-allah University of Medical Sciences Evaluation of the effectiveness of ZOUSH in burn wound healling Evaluation of the effectiveness of ZOUSH in second degree burn wound healing in terms of histopathology and changes in the expression of some genes involved in wound healing process 2020-09-22 anticipated 20 Complete https://irct.ir/trial/50013 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A small portion of the patient's wound is randomly selected and treated with ZOUSH. The rest of the wound is treated with standard amniotic dressing. By accident, here means that the burn is not intended for a specific area of the body. In addition, a special part of the burned area is not considered. If there is a random burn in each organ, a part of it will be selected for treatment with ZOUSH, Blinding description: The patient, pathologist, and genetic researcher are completely unaware of which area is receiving standard amniotic fluid treatment and which area is being treated with ZOUSH, and data analysis is performed by blinding. 0 (exploratory trials) Second degree burn wounds. Intervention 1: Intervention group:Part of the burn patient's skin is treated with ZOUSH ointment. This ointment contains Satureja khuzestaniea, Zataria multiflora and MenthaMozaffariani Jamzad with Honey, and Polyurethane. Used once on the burn and after seven days the effectiveness of the drug will be evaluated. Intervention 2: Intervention group: Part of the patient's skin is treated with a standard amniotic dressing. Sampling of this part is done on the seventh day after treatment to evaluate the effectiveness of treatment. Intervention 3: Control group: A portion of the patient's skin is biopsied and studied as a control before starting treatment. In this study, the case and control is the patient and its different parts of the skin before and after the treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Because the information of the participants is used in data analysis and the data file does not contain much information, there is no necessity to publish it.
public mohammad soleimani farsani
North Kargar
Tehran Iran (Islamic Republic of) 1418945398 +98 21 6657 0590 soleymani.mm@gmail.com Bagheiat-allah University of Medical Sciences scientific محمد سلیمانی فارسانی
North Kargar
Tehran Iran (Islamic Republic of) 1418945398 +98 21 6657 0590 soleymani.mm@gmail.com Bagheiat-allah University of Medical Sciences Iran (Islamic Republic of) second degree burn wound no limit no limit Both Burn wounds in aesthetically sensitive areas A history of previous trauma or burns to the burned area Patients' reluctance Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group:Part of the burn patient's skin is treated with ZOUSH ointment. This ointment contains Satureja khuzestaniea, Zataria multiflora and MenthaMozaffariani Jamzad with Honey, and Polyurethane. Used once on the burn and after seven days the effectiveness of the drug will be evaluated. Intervention group: Part of the patient's skin is treated with a standard amniotic dressing. Sampling of this part is done on the seventh day after treatment to evaluate the effectiveness of treatment. Control group: A portion of the patient's skin is biopsied and studied as a control before starting treatment. In this study, the case and control is the patient and its different parts of the skin before and after the treatment. The effect of ZOUSH ointment on the healing of second degree burn wounds. Timepoint: Evaluation of genetic and histopathological changes before and after treatment with ZOUSH and standard amniotic dressing. Method of measurement: 3 mm skin punch. Bagheiat-allah University of Medical Sciences Approved 2020-06-08 Ethics Committee of Baqiyatallah University of Medical Sciences No. 9, Majd Alley, North Kargar Street, Enghelab Square, Tehran Tehran Tehran Iran (Islamic Republic of)