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IRCT20200728048232N1 IRCT 2020-08-03 Shiraz University of Medical Sciences The effect of green coffee supplement on diabetic The effect of green coffee supplement on glycemic control, inflammatory index, lipid profile and anthropometry in type 2 diabetic patients 2018-07-23 anticipated 60 Complete https://irct.ir/trial/49950 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were assigned to one of the intervention and placebo groups based on Block Randomization method by Random Allocation Software, Blinding description: By preparing a placebo exactly like the supplement consumed, the participants did not know which of the groups they were in. 2 diabetes. Intervention 1: Intervention group:Take 800 mg of green coffee supplement daily, two 400 mg tablets daily. Intervention 2: Control group: Receive two placebos daily. Yes - There is a plan to make this available What will be shared: Part of the data, such as information about the main outcome When: 1399 To whom: If a similar study is performed Conditions: evryone Where to obtain: Zahra Moin Jahromi 09228031953 Postal code 7177916419 How to obtain: send email Comments:
public Zohre mazloom
Shiraz Razi Blvd. School of Nutrition
Siraz Iran (Islamic Republic of) ۱۴۳۳۶ - ۷۱۳۴۸ +98 71 3230 5410 zohreh.mazloom@gmail.com Shiraz University of Medical Sciences scientific Zahra Moein jahromi
Shiraz Razi Blvd. School of Nutrition
shiraz Iran (Islamic Republic of) ۱۴۳۳۶ - ۷۱۳۴۸ +98 71 3230 5410 niloufarmoein@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Definitive diagnosis of type 2 diabetes in patients was made by an associate clinical physician under ADA criteria. Duration of type 2 diabetes is at least 3 years The type and dose of drugs used in the last 6 months is constant No chronic (chronic, renal, hepatic, pulmonary, or chronic or acute inflammatory diseases, especially acute inflammation of the pancreas and endocarditis)No heart disease, short bowel syndrome, allergies and thyroid disease Do not use any dietary supplements in the last 6 months No pregnancy and lactation Willingness to participate in the study No allergies to green coffee 40 years 69 years Both Pregnancy during the study period Changes in medication dosage during the study period Occurrence of one of the above diseases during the study period Dissatisfaction with continuing to participate in the study Do not take less than 80% of the allocated amount of green coffee tablets or do not follow the study design for more than a week E11.8 Type 2 diabetes mellitus with unspecified complications Treatment - Other Placebo Intervention group:Take 800 mg of green coffee supplement daily, two 400 mg tablets daily Control group: Receive two placebos daily Blood Glu. Timepoint: at the first and end of the study. Method of measurement: Fasting blood glucose by glucose oxidase method. Weight. Timepoint: First week 4 and week 8 study. Method of measurement: Weight of people in light clothing without shoes and in the fasting state was measured by a digital scale (model 703 Seka) with an accuracy of 100 grams. Insulin sensitivity. Timepoint: at the first and end of the study. Method of measurement: HOMA Homeostasis. Lipid profile. Timepoint: at the first and end of the study. Method of measurement: Triglycerides, cholesterol and LDL by enzymatic and calorimetric methods using Roach II commercial kits, HDL by calorimetric enzymatic method using Cubas Roach commercial kits. Insulin sensitivity. Timepoint: at the first and end of the study. Method of measurement: Insulin was evaluated by chemiluminescence method (40). Insulin concentration was determined using the ELISA kit of the American company Monobind. Also, insulin resistance and its components were calculated using the HOMA Homeostasis Model (Index assessment) before and after the intervention as follows: Fasting insulin (microu / L) x fasting glucose (nmol / L) /22.5. Total antioxidant. Timepoint: at the first and end of the study. Method of measurement: The Ferric Reducing Ability of Plasma method was determined using the main ingredient tripyridyl-S-triazine. Total antioxidant capacity was measured using 40 mM hydrochloric acid, 3-aqueous, 6-aqueous sodium acetate and triazine solution at concentrated Fecl acetic acid at 593 nm. Shiraz University of Medical Sciences Approved 2019-01-12 Ethics committee of Shiraz University of Medical Sciences No270.40.Bahonar jonobi shiraz Fars Iran (Islamic Republic of)