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IRCT20191031045289N2 IRCT 2020-08-06 Shahid Beheshti University of Medical Sciences The effect of adding lasix to antihypertensive treatment in controlling postpartum hypertension in women with preeclampsia The effect of adding lasix to antihypertensive treatment in controlling postpartum hypertension in women with preeclampsia 2020-08-22 anticipated 116 Complete https://irct.ir/trial/49806 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients with inclusion criteria will be selected as available sample and then will be randomly divided into two groups of intervention and non-intervention. 3 Preeclampsia. Intervention 1: Intervention group: Patients in this group will be treated with nifedipine 10 mg every 8 hours. The static dose of nifedipine 10 mg will be increased each time the blood pressure is greater than 160/110. In this group, in addition to nifedipine, furosemide tablets of 20 mg once daily from 24 hours after delivery to 3 days later will be given. If additional medication is needed to control blood pressure, the patient will not be excluded from the study, but this will be recorded in the patient information. Intervention 2: Control group: Patients in this group will be treated with nifedipine 10 mg every 8 hours. The static dose of nifedipine 10 mg will be increased each time the blood pressure is greater than 110/160. In this group, patients will only be treated with nifedipine. If additional medication is needed to control blood pressure, the patient will not be excluded from the study, but this will be recorded in the patient information. Yes - There is a plan to make this available What will be shared: All participants' information and study results will be shared after anonymity. When: After printing the results To whom: It will be available to everyone. Conditions: Use of the data is permitted by citing the source. Where to obtain: Dr. Pegah Azadi dr.pegahazadi@gmail.com How to obtain: Contact Dr. Azadi via the email address provided. Comments:
public Pegah Azadi
No. 30, East 22 Ave., South Allameh St.
Tehran Iran (Islamic Republic of) 1997843341 +98 21 8857 8752 n.ghaemi.983@gmail.com Shahid Beheshti University of Medical Sciences scientific Pegah Azadi
No. 30, East 22 Ave., South Allameh St.
Tehran Iran (Islamic Republic of) 1997843341 +98 21 8857 8752 n.ghaemi.983@gmail.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Systolic blood pressure above 150 mm Hg Diastolic blood pressure above 100 mm Hg Urine rate more than 50 cc per hour Termination of treatment with magnesium sulfate no limit no limit Female History of chronic hypertension Blood pressure less than 150/100 mm Hg Use of diuretics Previous underlying renal disorders Having diabetes Hemodynamic instability Contraindications to the use of Lasix Hematocrit more than 37 O15.0 Eclampsia in pregnancy Treatment - Drugs Treatment - Drugs Intervention group: Patients in this group will be treated with nifedipine 10 mg every 8 hours. The static dose of nifedipine 10 mg will be increased each time the blood pressure is greater than 160/110. In this group, in addition to nifedipine, furosemide tablets of 20 mg once daily from 24 hours after delivery to 3 days later will be given. If additional medication is needed to control blood pressure, the patient will not be excluded from the study, but this will be recorded in the patient information. Control group: Patients in this group will be treated with nifedipine 10 mg every 8 hours. The static dose of nifedipine 10 mg will be increased each time the blood pressure is greater than 110/160. In this group, patients will only be treated with nifedipine. If additional medication is needed to control blood pressure, the patient will not be excluded from the study, but this will be recorded in the patient information. Postpartum blood pressure control. Timepoint: From 24 hours to 5 days after delivery. Method of measurement: Mercury sphygmomanometer. Shahid Beheshti University of Medical Sciences Approved 2020-05-26 Ethics committee of Shahid Beheshti University of Medical Sciences No 30, East 22 Ave., South allameh St. Tehran Tehran Iran (Islamic Republic of)