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IRCT20080901001159N28 IRCT 2020-07-20 Tehran University of Medical Sciences The effectiveness of PRP and Erbium laser in the treatment of dark circles around the eyes Assessing the effectiveness of the combination therapy with Erbium laser and PRP ( Platelet Rich Plasma) in the treatment of periorbital dark circles 2020-06-21 anticipated 32 Complete https://irct.ir/trial/49618 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this method, block randomization is used. 32 patients will be included in the study by available sampling method based on inclusion and exclusion criteria. Each patient was considered as a block and their left and right eyes were randomly assigned to two groups using cards with study groups written on them, Blinding description: On both sides of the face in the dark area around the patient's eye, an airbag laser will be performed, and without the patient knowing the location of each intervention group, after laser therapy, PRP will be used on one side of the face and physiological serum on the opposite side. 1-2 Eye dark circles. Intervention 1: Control group: (one side of the face) The dark area around the eye is first treated with Erbium laser, and then physiological serum is applied topically on the site for one hour. This method is repeated 3 times at intervals of 4 weeks. Intervention 2: Intervention group: (other side of the face) The dark area around the eye is first treated with Erbium laser, and then PRP is applied topically on the site for one hour. This method is repeated 3 times at intervals of 4 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Shiva Alavi
No 4, Maryam Alley, South Kamraniyeh Street, Tehran, Iran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2220 1710 Shiva.alavi@yahoo.com Skin and Stem cell Research Center of Tehran University of Medical Sciences scientific Mohammad Ali Nilforoushzadeh
No 4, Maryam Alley, South Kamraniyeh Street, Tehran, Iran
Tehran Iran (Islamic Republic of) 1937957511 +98 21 2220 1710 nilforoosh@sina.tums.ac.ir Skin and Stem cell Research Center of Tehran University of Medical Sciences Iran (Islamic Republic of) The cause of darkness, structural and reducing fat in this area is not Age between 18 and 50 years old 18 years 50 years Both Active infection in the face Pregnancy and breastfeeding History of cancer - - Treatment - Other Treatment - Other Control group: (one side of the face) The dark area around the eye is first treated with Erbium laser, and then physiological serum is applied topically on the site for one hour. This method is repeated 3 times at intervals of 4 weeks. Intervention group: (other side of the face) The dark area around the eye is first treated with Erbium laser, and then PRP is applied topically on the site for one hour. This method is repeated 3 times at intervals of 4 weeks. Preorbital hyperpigmentation. Timepoint: Session 0, 4 and 6 during treatment and 3 months after treatment. Method of measurement: Intensity of the darkening of the skin around the eyes compared to other areas of the face with Mexameter device. Satisfaction amount. Timepoint: After completion of treatment. Method of measurement: Comparison of reduction preorbital hyper pigmentation by patient , before and after treatment According to schedule ( score 0 to 10 ). Tehran University of Medical Sciences Approved 2019-01-30 Ethics Committee of Tehran University of Medical Sciences Tehran University of Medical Sciences, Keshavarz blvd. Tehran Tehran Iran (Islamic Republic of)