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IRCT20101211005362N25 IRCT 2020-07-30 Esfahan University of Medical Sciences Comparative effect of sufentanil and dexmedetomidin on myoclonus incidence and pain induced by anesthesia with etomidate Comparative effect of sufentanil and dexmedetomidin on myoclonus incidence and pain induced by anesthesia with etomidate: a double blin clinical trial study 2018-07-21 anticipated 108 Complete https://irct.ir/trial/49582 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Eligible additions were assigned to the three study groups using randomized block methods with a size of 6 blocks and using random allocation software, Blinding description: In the present study, the injector and the data collector also had no information and the participants did not know the type of drug received. The injector has no knowledge of the type of drug (blinding) and the data collector has no knowledge of the type of drug (both sides of the blind). Premedication drugs are coated in 10 ml syringes with prior coding. After administering 100% oxygen, premedication is given intravenously over a period of 2 minutes. The second anesthesiologist, who is not aware of grouping, then records the myoclonus movements and pain of the patients based on scoring. The first anesthesiologist injects only medications and collects information such as pain and myoclonus, mean arterial pressure, heart rate, blood oxygen saturation percentage at the general time 0, 5, 10, 15, 30, and 60 minutes after atomiditis. They do not have any information about the type of medicine they received. N/A pain. Intervention 1: In the present study, there are two intervention groups and one control group. 1- In the first intervention group, sufentanil is injected intravenously at the rate of 0.1 micrograms per kilogram. Intervention 2: Intervention group: 2- In the second intervention group, dexmedetomidine is injected intravenously at the rate of 0.5 micrograms per kilogram. Intervention 3: Control group: 3- In the control group, distilled water is injected in the amount of 5 cc. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information
public Mohammadreza Safavi
Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan
Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan Iran (Islamic Republic of) 6215423542 +98 31 1273 2659 safavi@med.mui.ac.ir Esfahan University of Medical Sciences scientific Mohammadreza Safavi
Anesthesiology and Critical Care Research Center,Isfahan University of Medical Sciences, Isfahan, Iran
isfahan Iran (Islamic Republic of) 8174675731 +98 31 1625 5555 safavi@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients 18 to 60 years ASA Class 1 and 2 Candidate for surgery and in need of general anesthesia Agree to participate in the study 18 years 60 years Both heart and liver failure, mental illness, neurological diseases, opioid allergy Drug addiction Y48.2 premedication anesthetic Treatment - Drugs Treatment - Drugs Treatment - Drugs In the present study, there are two intervention groups and one control group. 1- In the first intervention group, sufentanil is injected intravenously at the rate of 0.1 micrograms per kilogram Intervention group: 2- In the second intervention group, dexmedetomidine is injected intravenously at the rate of 0.5 micrograms per kilogram. Control group: 3- In the control group, distilled water is injected in the amount of 5 cc. Myoclonus. Timepoint: Minutes 0 - 5 - 10 - 15 - 30 - 60 - 60 after atomiditis injection. Method of measurement: Pulse oximeter. Esfahan University of Medical Sciences Approved 2020-05-08 Isfahan University of Medical Sciences Isfahan-University of Medical Sciences, School of Medicine Isfahan Isfehan Iran (Islamic Republic of)