]>
IRCT20190506043492N4 IRCT 2020-06-22 Ahvaz University of Medical Sciences Investigation of the effect of inhaled heparin in the treatment of patients with adult respiratory distress syndrome hospitalized in the intensive care unit Investigation of the effect of inhaled heparin in the treatment of patients with adult respiratory distress syndrome hospitalized in the intensive care unit 2020-04-08 anticipated 60 Complete https://irct.ir/trial/49030 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were randomly selected and divided into two groups of intervention (heparin recipient) and control (normal saline recipient) through a table of random numbers assigned to even numbers for the intervention group and individual numbers for the control group, Blinding description: In this study, the person who injected the drug was unaware that the syringe contained heparin or normal saline because the drug was taken by another anesthesiologist and stamped 1 and 2, and the person who took the blood sample for coagulation tests Patients were unaware of the type of intervention and the type of medication that had been injected for the patients. In this study, statistical analyzer was also unaware of the type of groups. 3 Acute respiratory distress syndrome. Intervention 1: Intervention group: Patients in the intervention group In addition to routine care, 5,000 units are used every 12 hours for 7 days.The heparin used is 5,000 units produced by Iran Pakhsh Broadcasting Company, which is diluted with 2 cc of distilled water and then poured into a nebulizer device and the nebulizer is connected to the chip pipe and the ventilator is connected. Intervention 2: Control group: In addition to routine care, patients in the control group poured 2 cc of normal saline into the nebulizer every 12 hours for 7 days, and the nebulizer was connected to the chip tube and then to the ventilator. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Nastaran sadat Hoseini
Ahvaz Jundishapur University of Medical Sciences, GolestanBLvd
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3373 8383 Eglantin92@gmail.com Ahvaz University of Medical Sciences scientific Nastaran sadat Hoseini
Ahvaz Jundishapur University of Medical Sciences, GolestanBLvd
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3373 8383 Eglantin92@gmail.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Patients 18 to 60 years Under mechanical ventilation for more than 48 hours Respiratory index PAO2 / FIO2 ≤200 mmhg Bilateral pulmonary infiltration in the chest x-ray Lack of heart disease and previous lung disease Positive end expiratory pressure or PEEP≥ ventilator 5 cmh2 No history of intracerebral hemorrhage in the past 12 months No history of heparin-induced thrombocytopenia 18 years 60 years Both Dissatisfaction to continue working on the study Hypersensitivity to heparin Uncontrolled bleeding or bleeding disorders PTT and INR impaired Patients receiving therapeutic doses of heparin, anaxaparin and warfarin J80 Acute respiratory distress syndrome Treatment - Drugs Placebo Intervention group: Patients in the intervention group In addition to routine care, 5,000 units are used every 12 hours for 7 days.The heparin used is 5,000 units produced by Iran Pakhsh Broadcasting Company, which is diluted with 2 cc of distilled water and then poured into a nebulizer device and the nebulizer is connected to the chip pipe and the ventilator is connected. Control group: In addition to routine care, patients in the control group poured 2 cc of normal saline into the nebulizer every 12 hours for 7 days, and the nebulizer was connected to the chip tube and then to the ventilator. Respiratory index: PAO2 / FIO2. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator. Arterial blood gas parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: ABG test. The amount of PEEP required for effective mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: Ventilator. The time required for mechanical ventilation. Timepoint: 1 to 7 days after the intervention. Method of measurement: The number of days it has been subjected to mechanical ventilationnumber. Mortality rate is 48 hours and 7 days. Timepoint: 1 to 7 days after the intervention. Method of measurement: Mortality rate. Respiratory parameters. Timepoint: 1 to 7 days after the intervention. Method of measurement: Lung capacity، Tidal Volume, Respiratory rate, Minute Ventilation, Paco2. Ahvaz University of Medical Sciences Approved 2020-04-25 Ethics committee of ahvaz jundishapur University of Medical Sciences Ground Floor, Central Library, Ahvaz Jundishapur University of Medical Sciences, Golestan BLvd., Ahvaz Ahvaz Khouzestan Iran (Islamic Republic of)