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IRCT20190506043492N5 IRCT 2020-07-07 Ahvaz University of Medical Sciences Induction of anesthesia with etomidate and propofol on surgical stress responses Comparison of induction of anesthesia with etomidate and propofol on surgical stress responses in spinal elective surgery 2018-04-21 anticipated 60 Complete https://irct.ir/trial/49007 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients were randomly selected and randomly divided into two groups (Atomidate receiver) and the second group (Propofol receiver) through random number tables, so that for the first group, individual numbers were used and for the second group, even numbers were used, Blinding description: In this study, patients were unaware that they were in the atomidate group or propofol, a person who took a blood sample to check for laboratory tests related to the patient's stress response, and a statistical analyzer who did not know the type of intervention. 3 Stress Rresponse. Intervention 1: First Intervention group:In order to induce anesthesia, 0.3 mg / kg of atomidate (oxy-nac, Elixir Pharmaceuticals, Boroujerd, Iran) were injected intravenously. Intervention 2: Second Intervention group: In order to induce anesthesia, 2.2 mg / kg of propofol (Oxy-Nak, Elixir Pharmacy, Boroujerd, Iran) was injected intravenously. Intervention 3: Control group: In order to induce anesthesia, 5 mg / kg sodium thiopental (Oxy-Nak, Elixir Pharmacy, Boroujerd, Iran) was injected intravenously. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information.
public Mohamad Mahdi Mina
Ahvaz Jundishapur University of Medical Sciences, GolestanBLvd
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3373 8383 Mahdi552m@hotmail.com Ahvaz University of Medical Sciences scientific Farahzad Janat Makan
Ahvaz Jundishapur University of Medical Sciences, GolestanBLvd
Ahvaz Iran (Islamic Republic of) 6135715794 +98 61 3373 8383 Fjanatmakan@yahoo.com Ahvaz University of Medical Sciences Iran (Islamic Republic of) Lack of severe bacterial or chronic viral infection Do not take antidepressants Lack of autoimmune diseases Lack of connective tissue disease Lack of liver and kidney disorders Lack of peripheral vascular disease, heart failure, thyroid disease Lack of mental disorders 18 years 60 years Both Dissatisfaction with continuing to study T88.5 Other complications of anaesthesia Prevention Prevention Prevention First Intervention group:In order to induce anesthesia, 0.3 mg / kg of atomidate (oxy-nac, Elixir Pharmaceuticals, Boroujerd, Iran) were injected intravenously. Second Intervention group: In order to induce anesthesia, 2.2 mg / kg of propofol (Oxy-Nak, Elixir Pharmacy, Boroujerd, Iran) was injected intravenously. Control group: In order to induce anesthesia, 5 mg / kg sodium thiopental (Oxy-Nak, Elixir Pharmacy, Boroujerd, Iran) was injected intravenously. Serum level IL-1. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: IL-1 blood serum levels in a blood biochemistry test. Serum level IL-2. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Blood serum IL-2 levels in a blood biochemistry test. Serum albumin levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum levels of blood albumin in a blood biochemistry test. Serum glucose levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum blood glucose levels in a blood biochemistry test. C-reactive-protein (Crp) Level. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum Crp blood levels in blood biochemistry tests. Serum cortisol levels. Timepoint: Immediately before surgery and anesthesia, 24 hours, 48 hours and one week after surgery. Method of measurement: Serum levels of blood cortisol in a blood biochemistry test. Ahvaz University of Medical Sciences Approved 2019-10-30 Ethics Committee of Ahvaz Jundishapur University of Medical Sciences Ground Floor, Central Library, Ahvaz Jundishapur University of Medical Sciences, Golestan BLvd., Ahvaz Ahvaz Khouzestan Iran (Islamic Republic of)