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IRCT20160307026950N21 IRCT 2020-06-29 Esfahan University of Medical Sciences Study of effectiveness of propofol dosage in prevention of nausa and vomiting in some surgeris Study and comparison of two different doses of propofol in prevention of nausea and vomiting in spinal discectomy 2018-03-21 anticipated 48 Complete https://irct.ir/trial/48971 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: After sampling and selecting the list of patients, using spss software, edit 18, the order of patients entering the 3 groups under study is determined completely randomly based on the order in the random list of spss, Blinding description: The doctor and the patient do not know the type of drug combination used. 3 Condition 1: Nausea. Condition 2: Vomit. Intervention 1: Intervention group 1: First, patients are given the necessary information about the type of operation and sedation method, and written consent is obtained from each of them. Vital symptoms such as blood pressure, heart rate, o2sat drop, patient stay in recovery, and nausea and vomiting were recorded on the form. Then a low-dose propofol (0.1 mg / Kg) is prescribed for group 1, and patients' nausea and vomiting are checked until recovery. The implementation method is based on the modified Aldred score criterion. Intervention 2: Intervention group 2: First, patients are given the necessary information about the type of operation and sedation method, and written consent is obtained from each of them. Vital symptoms such as blood pressure, heart rate, o2sat drop, patient stay in recovery, and nausea and vomiting were recorded on the form. The usual dose of propofol (0.25 mg / Kg) is then prescribed for group 2 and the patient's nausea and vomiting are checked until recovery. The implementation method is based on the modified Aldred score criterion. Intervention 3: Control group: First, patients are given the necessary information about the type of procedure and sedation method, and written consent is obtained from each of them. Vital signs such as blood pressure, heart rate, o2sat drop, patient stay in recovery, and nausea and vomiting were recorded on the form. Normal saline (0.25 mg / kg) is then administered and the patient's nausea and vomiting are checked until recovery. The implementation method is based on the modified Aldred score criterion. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Because I have not yet received permission from the budget provider of this project (Isfahan University of Medical Sciences)
public Samin Mohammadi
Tohid Street
Isfahan Iran (Islamic Republic of) ۸۱۷۳۹۳۳۷۵۲ +98 31 3624 8494 saminmhmd@gmail.com Esfahan University of Medical Sciences scientific Dr. Behzad Nazemroaya
Department of Anesthesiology, AL-Zahra Hospital
Isfahan Iran (Islamic Republic of) 8146713543 0098316202020 behzad_nazem@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) The person should not have received any sedative or narcotic drugs No gastrointestinal problems such as reflux Patients should be between 18 and 65 years old. Having a informed consent to enter the research 18 years 65 years Both If there is any change in the relaxation method and the change in the surgical method, the patient should be excluded from the study. The patient's age is more than 65 years The patient's age is less than 18 years Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: First, patients are given the necessary information about the type of operation and sedation method, and written consent is obtained from each of them. Vital symptoms such as blood pressure, heart rate, o2sat drop, patient stay in recovery, and nausea and vomiting were recorded on the form. Then a low-dose propofol (0.1 mg / Kg) is prescribed for group 1, and patients' nausea and vomiting are checked until recovery. The implementation method is based on the modified Aldred score criterion. Intervention group 2: First, patients are given the necessary information about the type of operation and sedation method, and written consent is obtained from each of them. Vital symptoms such as blood pressure, heart rate, o2sat drop, patient stay in recovery, and nausea and vomiting were recorded on the form. The usual dose of propofol (0.25 mg / Kg) is then prescribed for group 2 and the patient's nausea and vomiting are checked until recovery. The implementation method is based on the modified Aldred score criterion. Control group: First, patients are given the necessary information about the type of procedure and sedation method, and written consent is obtained from each of them. Vital signs such as blood pressure, heart rate, o2sat drop, patient stay in recovery, and nausea and vomiting were recorded on the form. Normal saline (0.25 mg / kg) is then administered and the patient's nausea and vomiting are checked until recovery. The implementation method is based on the modified Aldred score criterion. Nausea score based on VAS criteria. Timepoint: During recovery time after surgery. Method of measurement: questionnaire. To vomit or not to vomit. Timepoint: During recovery time after surgery. Method of measurement: questionnaire. Esfahan University of Medical Sciences Approved 2019-05-24 Ethics committee of Isfahan University of Medical Sciences Hezarjrib Street, Daneshgah Blvd, isfahan Isfehan Iran (Islamic Republic of)