]>
IRCT20180625040232N4 IRCT 2020-06-17 Oroumia University of Medical Sciences The effects of tranexamic acid on bleeding control The effects of tranexamic acid on bleeding control during and after percutaneous nephrolithotomy (PCNL) 2013-08-23 anticipated 108 Complete https://irct.ir/trial/48796 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study, all eligible patients were assigned to control and intervention (tranexamic ) groups using random sequence extraction from the computer (via www.randomization.com) and simple randomization. The resulting random numbers, i.e. the allocation of patients to groups, was concealed using sealed envelopes, Blinding description: Random allocation was made among patients and assigned to Card Intervention Group No. 1 and to Plasbo Card Group No. 2. Participants and clinical caregivers were unaware of the allocation of individuals in each of the study groups involved and the placebo. 3 Bleeding. Intervention 1: Intervention group: In the intervention group, 1 gr of tranexamic acid (Caspian Tamin Pharmaceutical Company) is diluted in 100 ml normal saline and injected into nephrostomy drain (intravenously) immediately after surgery. The catheter is then clamped for 30 minutes to prevent leakage. Intervention 2: Control group: In the control group received placebo (1gr at the beginning and 5mg every 8hrs for 3days) capsules (starch) of the same form and dose. Yes - There is a plan to make this available What will be shared: Any information without the need for patients' names will be available When: Six months after publication To whom: Faculty members of medical universities Conditions: For research purposes Where to obtain: Email to Dr. Saman Farshid farshid.s@umsu.ac.ir How to obtain: Email to Dr. Saman Farshid farshid.s@umsu.ac.ir Comments:
public Saman Farshid
Imam Khomeini hospital, Ershad Ave, Urmia
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3346 9931 samanf63@gmail.com Oroumia University of Medical Sciences scientific Saman Farshid
Imam Khomeini hospital, Ershad Ave, Urmia
Urmia Iran (Islamic Republic of) 5714783734 +98 44 3346 9931 Farshid.s@umsu.ac.ir Oroumia University of Medical Sciences Iran (Islamic Republic of) Age between 18-65 years ASA class >III Not having coagulopathy 18 years 65 years Both Need to embed Double J Stent Prediction of need to transfusion during surgery Patients with coagulopathy D68.32 Hemorrhagic disorder due to extrinsic circulating anticoagulants Treatment - Drugs Treatment - Drugs Intervention group: In the intervention group, 1 gr of tranexamic acid (Caspian Tamin Pharmaceutical Company) is diluted in 100 ml normal saline and injected into nephrostomy drain (intravenously) immediately after surgery. The catheter is then clamped for 30 minutes to prevent leakage. Control group: In the control group received placebo (1gr at the beginning and 5mg every 8hrs for 3days) capsules (starch) of the same form and dose. Bleeding. Timepoint: 24 hours before surgery and 48 hours after surgery. Method of measurement: Blood sampling. Hospital stay days. Timepoint: Once, at the time of discharge. Method of measurement: Calculating hospital stay days from admission to discharge. Urmia University of Medical Sciences Approved 2013-12-03 Ethics committee of Urmia University of Medical Sciences Resalat Blvd-Emergency Alley, Urmia, Vest Azarbaijan Urmia West Azarbaijan Iran (Islamic Republic of)