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IRCT20200609047707N1 IRCT 2020-06-24 Esfarayen University of Medical Sciences Effective of Elman tablet on COVID-19 infection severity Effective of Elman tablet on illness severity and length of hospital stay in the patients with COVID-19 infection 2020-07-09 anticipated 90 Complete https://irct.ir/trial/48764 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The randomization method is simple. Random units are each of patients infected with covid-19 that admitted to the emergency department. Also, The randomization tool is a random number table. The researcher select one of the numbers in the random numbers table and moves to the right and down. Record the numbers and assign them to different study groups whose numbers are already specified. 3 Patients infected with Covid-19. Intervention 1: First Intervention group (Elman Tablet): The tablet has an effective drug combination of L-cysteine, C3H7NO2S chemical formula and chemical structure of HS-CH2-CH (NH2) -COOH with L stereochemistry and a molar mass of 121.16 grams per mole and soluble in water. Each Elman tablet contains 60 mg of L-cysteine (Pharmaceutical active ingredient). Each patient takes this pill three times every 8 hours. It is recommended to take this medicine at least two hours apart from the prescription of the routine medications for six days. Manufacturing Company is Simorgh Attar Neishabour Pharmaceutical . It is prescribed along with routine drugs for treatment of covid-19. Intervention 2: Second Intervention group (Placebo): It contains a combination of malodextrin, an oligo or polysaccharide with the formula C6nH10n + 2 O5n + 1, and is obtained from starch hydrolysis in a simple process. The powder is white and soluble in water. The placebo is given with a very similar appearance to the original medicine and is given orally every 8 hours for six days. Drugs associated with the treatment of Qovid-19 disease are prescribed according to the routine. Intervention 3: Control group: Drugs associated with the treatment of Covid-19 disease are prescribed according to the routine( hydroxychloroquine 200 mg and Kaletra). Yes - There is a plan to make this available What will be shared: Document will be registered "Pajouhan" system after completion of the study . Also, participants general information and the effectiveness of interventions will be recorded in the article. When: Accessibility after publish of article To whom: People interested in medicine scope Conditions: People looking for ways to covid-19 recovery who can access the data. Where to obtain: Esfarāyen faculty of medical sciences, imama Reza Street, Esfarāyen, North Khorasan How to obtain: They can access to data through below email as soon as possible s.j.hoseini2016@gmail.com Comments:
public Seyed Javad Hosseini
Esfarayen faculty of medical sciences, Imam Reza street, Esfarayen, North Khorasan
Esfarayen Iran (Islamic Republic of) 9661777944 0098 5831550000- 602 S.j.hoseini2016@gmail.com Esfarayen University of Medical Sciences scientific Essa Tohidi
Esfarayen faculty of medical sciences, imam Reza Street, Esfarayen town, North Khorasan, Iran
Esfarayen Iran (Islamic Republic of) 96617-77944 +98 58 3722 9050 Issatohidi201648@gmail.com Esfarayen University of Medical Sciences Iran (Islamic Republic of) Patients diagnosed with COVID-19 disease based on PCR test The level of consciousness should be 15 18 years 65 years Both Pregnancy and lactation Connect the patient to the ventilator Low blood pressure at the beginning of the study (below 80/12) Has a history of gastrointestinal bleeding or active bleeding in the body Patients with immunodeficiency (under chemotherapy, organ transplantation and bone marrow transplantation, and patients with autoimmune diseases) U07.1 Covid-19 Treatment - Drugs Placebo N/A First Intervention group (Elman Tablet): The tablet has an effective drug combination of L-cysteine, C3H7NO2S chemical formula and chemical structure of HS-CH2-CH (NH2) -COOH with L stereochemistry and a molar mass of 121.16 grams per mole and soluble in water. Each Elman tablet contains 60 mg of L-cysteine (Pharmaceutical active ingredient). Each patient takes this pill three times every 8 hours. It is recommended to take this medicine at least two hours apart from the prescription of the routine medications for six days. Manufacturing Company is Simorgh Attar Neishabour Pharmaceutical . It is prescribed along with routine drugs for treatment of covid-19. Second Intervention group (Placebo): It contains a combination of malodextrin, an oligo or polysaccharide with the formula C6nH10n + 2 O5n + 1, and is obtained from starch hydrolysis in a simple process. The powder is white and soluble in water. The placebo is given with a very similar appearance to the original medicine and is given orally every 8 hours for six days. Drugs associated with the treatment of Qovid-19 disease are prescribed according to the routine. Control group: Drugs associated with the treatment of Covid-19 disease are prescribed according to the routine( hydroxychloroquine 200 mg and Kaletra). Illness severity. Timepoint: Every 12 hours for six day. Method of measurement: Using the checklist. Length of hospital stay. Timepoint: It is controlled daily. Method of measurement: Calculate the number of days hospitalized within the corona ward. Esfarayen University of Medical Sciences Approved 2020-06-07 Ethics committee of Esfarayen faculty of medical sciences Esfarayen faculty of medical sciences, Imam Reza street, Esfarayen, North Khorasan Esfarayen North Khorasan Iran (Islamic Republic of)