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IRCT20161026030510N3 IRCT 2020-09-29 Iran University of Medical Sciences Evaluation of the effectiveness of electrical extracranial stimulation of the brain (TDCS) combined with matrix psychotherapy in comparison with matrix psychotherapy alone in reducing cravings and improving cognitive functions in the methamphetamine withdrawal phase Evaluation of the effectiveness of electrical extracranial stimulation of the brain (TDCS) combined with matrix psychotherapy in comparison with matrix psychotherapy alone in reducing cravings and improving cognitive functions in the methamphetamine withdrawal phase 2019-11-11 anticipated 60 Complete https://irct.ir/trial/48726 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Randomization performed with simple method and random numbers generated by computer software (Stat Trek) which choose the random numbers.Then, we consider the specific numbers for both groups for example: the even numbers are for experimental group and odd numbers are for the control group. N/A Methamphetamine abusers. Intervention 1: Rreal tDCS: 11 patients in this group received tDCS with craving therapy protocol during 15 sessions; they also received 24 sessions of psychological therapy based on the matrix protocol. Therapeutic protocol of intervention group (real TDCS) included 2MA current for 20 minutes in form of DC current. In this research, the direct electrical current was received from an electric current generator that works with batteries then transferred to a pair of electrodes 5×7 (35 cm2). Carbon electrodes were placed inside the sponge coating impregnated with serum.The matrix protocol includes: a variety of psychological therapies for patients. Intervention 2: Sham tDCS: 8 patients in group received 15 sessions tDCS with craving treatment protocol through shame method and without effectiveness (without informing the patient); they also received 24 sessions of psychological therapy based on the matrix protocol. The matrix protocol includes: a variety of psychological therapies for patients. Intervention 3: Control group: 9 patients in group 3- as a control group- just received 24 sessions of psychological therapy based on the matrix protocol. The matrix protocol includes: a variety of psychological therapies for patients. Yes - There is a plan to make this available What will be shared: Clinical and cognitive outcomes of patients after the intervention When: 2020 To whom: Researchers Conditions: Researchers from all scientific centers Where to obtain: Email How to obtain: Email - 3 Weeks Comments:
public Dr. Reza Arezoomandan
Mansouri St, Faculty of Behavioral Sciences and Mental Health
Tehran Iran (Islamic Republic of) 1445613111 +98 21 6655 1655 Arezoomandan@yahoo.com Iran University of Medical Sciences scientific Dr.Reza Arezoomandan
Mansouri St., Faculty of Behavioral Sciences and Mental Health
Tehran Iran (Islamic Republic of) 1445613111 +98 21 6655 1555 Arezoomandan@yahoo.com Iran University of Medical Sciences Iran (Islamic Republic of) Patients who had referred to the common accommodation and outpatient treatment center in order to quite methamphetamine addiction Having at least 12-month experience of methamphetamine addiction based on the DSM-5 criteria Drug abuse in 6 days a week, Avoiding any drug or stimulant abuse except for cigarette Age: 18-50, Consent signing of ethical form. 18 years 50 years Male Having any psychiatric disorder except for drug-related disorders, Traumatic brain injuries (medium to severe) along with neurologic deficits or suffering from acute and unstable medical conditions that may put the patient at risk, Having metal implants inside the skull, mental retardation, organic brain disorder, having serious suicidal thoughts, Receiving another medical or psychological intervention at the same time. Rehabilitation Rehabilitation Prevention Rreal tDCS: 11 patients in this group received tDCS with craving therapy protocol during 15 sessions; they also received 24 sessions of psychological therapy based on the matrix protocol. Therapeutic protocol of intervention group (real TDCS) included 2MA current for 20 minutes in form of DC current. In this research, the direct electrical current was received from an electric current generator that works with batteries then transferred to a pair of electrodes 5×7 (35 cm2). Carbon electrodes were placed inside the sponge coating impregnated with serum.The matrix protocol includes: a variety of psychological therapies for patients Sham tDCS: 8 patients in group received 15 sessions tDCS with craving treatment protocol through shame method and without effectiveness (without informing the patient); they also received 24 sessions of psychological therapy based on the matrix protocol. The matrix protocol includes: a variety of psychological therapies for patients Control group: 9 patients in group 3- as a control group- just received 24 sessions of psychological therapy based on the matrix protocol. The matrix protocol includes: a variety of psychological therapies for patients Craving Score in Craving questionnaire. Timepoint: Before and after the intervention. Method of measurement: Craving questionnaire or OCDUS - Obsessive Compulsive Drug Use Scale. Working memory score in Wechsler subscale. Timepoint: Before and after the intervention. Method of measurement: The digit span subscale of Wechsler Intelligence Scale. Cognitive function score in Wisconsin Scale. Timepoint: Before and after the intervention. Method of measurement: Wisconsin Test. . Approved 2019-11-11 Ethics committee of Iran University of Medical Sciences Iran University of Medical Sciences,Shahid Hemmat Highway; Next to Milad Tower Tehran Tehran Iran (Islamic Republic of)