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IRCT20200507047344N1 IRCT 2020-07-13 Esfahan University of Medical Sciences Effectiveness of sucralfate in treatment of oral paraquat poisoning Evaluation and comparison of sucralfate effect in treatment of oral paraquat poisoning in comparison with non-prescribed oral poisoning. 2020-09-22 anticipated 60 Complete https://irct.ir/trial/48579 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: 60 patients with paraquat poisoning who were eligible for inclusion in the study will be enrolled by the simple randomized method. Then they will be divided into two groups of 30 using the random block method with 3 blocks. So that the first three cases are separated and assigned to group one, then the next three cases are separated and assigned to group two and this will be continued three by three in the same way till the ending of samples, Blinding description: Both the sucralfate and normal saline ingredients are pre-prepared to a certain extent and are labeled with the letters A and B and given to the resident to use on gastric lavage. 3 Paraquat poisoning. Intervention 1: Intervention group: In the intervention group, gastric lavage with sucralfate will be performed at the rate of 5 grams per 2 liters of water. In this way, after preparing the Sucralfite solution in advance with the B label, the patient corresponding to this intervention, which is determined by randomization, is given gastric lavage. Intervention 2: Control group: A patient poisoned with oral paraquat is given gastric lavage without the use of a Sucralfate solution and only with water. Yes - There is a plan to make this available What will be shared: Total data after deleting the names When: Since July 1401 To whom: University researchers Conditions: None Where to obtain: shafeajafar@med.mui.ac.ir How to obtain: one month Comments:
public Shafeajafar Zoofaghari
No. 9, Behzad Alley, Sharif Vaqefi Street.
Isfahan Iran (Islamic Republic of) 8153797567 +98 31 3268 7610 shafeajafar@med.mui.ac.ir Esfahan University of Medical Sciences scientific Shafeajafar Zoofaghari
No. 9, Behzad Alley, Sharif Vaqefi Street.
Isfahan Iran (Islamic Republic of) 8153797567 +98 31 3268 7610 shafeajafar@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Oral paraquat poisoning During recent past day Informed consent 18 years no limit Both More than 24 hours have passed since the poisoning No consent T60.3X2A Toxic effect of herbicides and fungicides, intentional self-harm, initial encounter Treatment - Drugs Treatment - Drugs Intervention group: In the intervention group, gastric lavage with sucralfate will be performed at the rate of 5 grams per 2 liters of water. In this way, after preparing the Sucralfite solution in advance with the B label, the patient corresponding to this intervention, which is determined by randomization, is given gastric lavage. Control group: A patient poisoned with oral paraquat is given gastric lavage without the use of a Sucralfate solution and only with water. Lung involvement. Timepoint: See chest x-ray at the beginning of the entrance and on the third, fifth and seventh days of hospitalization and at the time of discharge. Method of measurement: Chest x-ray. Esfahan University of Medical Sciences Approved 2020-04-12 Ethics committee of Isfahan University of Medical Sciences Hezar Jarib Ave, Azadi Square. Isfahan Isfehan Iran (Islamic Republic of)