IRCT20150221021159N3 IRCT 2020-06-23 Esfahan University of Medical Sciences The effect of melatonin and N-acetyl cysteine on colistin-associated nephrotoxicity Evaluation of the protective effect of melatonin and N-acetyl cysteine on colistin-induced nephrotoxicity in critically ill patients: A randomized, controlled clinical trial 2018-12-09 anticipated 51 Complete https://irct.ir/trial/48361 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Numbers from 1 to 51 were written on the separated cards, and 17 cards were assigned to each group of melatonin, N-acetyl cysteine, and control. These cards were placed in the box, and one card was selected randomly from these shuffled cards for each eligible patient on the study recruitment day. According to the number of the chosen card, patients were categorized into a specific group. 3 Acute kidney failure. Intervention 1: First intervention group: Melatonin tablets made in nature made company are administered orally at the dose of 3 mg twice daily for 5 days, on the same date of starting colistin. Intervention 2: Control group: No intervention was conducted in addition to standard care to prevent colistin-induced nephrotoxicity. Intervention 3: Second intervention group: N-acetyl cysteine tablet are administered orally at the dose of 600 mg twice daily for 5 days, on the same date of starting colistin. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information