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IRCT20151108024938N3 IRCT 2023-08-21 Mashhad University of Medical Sciences Effect of L-carnitine on COVID-19 Comparison of the complementary effect of L-carnitine and placebo on the clinical outcomes of patients with COVID-19 (2019-nCov) admitted to the intensive care unit 2020-04-20 anticipated 42 Complete https://irct.ir/trial/48143 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Simple randomization , block method. Randomization was performed by random block method using statistical software. In order to apply concealment in the randomization process, unique codes will be used on drug boxes, the desired code is also generated by the online site, Blinding description: The patient, medical staff, and interventionist are all aware of the type of study and the contents of the medication and placebo packages, and only the fact that the codes of the medications remain hidden from these individuals. 3 Condition 1: Acute respiratory infection caused by coronavirus. Condition 2: Acute respiratory infection caused by coronavirus. Intervention 1: Intervention group: Receiver of 3000 mg of L-carnitine daily for 7 days by gavage from Kasra-zist takhmir bonyan company. Intervention 2: Control group: Receiving 10 cc pasteurized drinking water daily for 7 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Seyed Mostafa Arabi
Mashhad University of Medical Sciences; Azadi square
Mashhad Iran (Islamic Republic of) 913881394 +98 51 3882 8574 arabim941@mums.ac.ir Mashhad University of Medical Sciences scientific Seyed Mostafa Arabi
Mashhad University of Medical Sciences; Azadi square
mashhad Iran (Islamic Republic of) 9138813944 +98 51 3882 7033 arabim941@mums.ac.ir Mashhad University of Medical Sciences Iran (Islamic Republic of) All patients COVID-19, admitted to intensive care unit Age 18-65 years old Satisfaction to participate in the study 18 years 65 years Both Covid-19 with mold diarrhea History of L-carnitine allergy Use of anticonvulsant drugs Hemodialysis U07.2 U07.1 COVID-19, virus not identified COVID-19, virus identified Treatment - Drugs Placebo Intervention group: Receiver of 3000 mg of L-carnitine daily for 7 days by gavage from Kasra-zist takhmir bonyan company Control group: Receiving 10 cc pasteurized drinking water daily for 7 days Ventilator dependence. Timepoint: Before and 7 days after intervention. Method of measurement: Using ABG and the opinion of an anesthesiologist. C-reactive protein (CRP). Timepoint: Before and 7 days after intervention. Method of measurement: Quantitative method, by ELISA method. Mortality within the intensive care unit. Timepoint: Before intervention and 7 days after intervention. Method of measurement: Observe the occurrence. The ratio of neutrophils to lymphocytes. Timepoint: Before intervention and 7 days after intervention. Method of measurement: Using a complete blood test. Blood levels of lactate dehydrogenase. Timepoint: Before intervention and 7 days after intervention. Method of measurement: Enzymatic method. The incidence of sepsis. Timepoint: Before intervention and 7 days after intervention. Method of measurement: Based on the diagnosis of the treating physician and SIRS criteria. The incidence of respiratory distress. Timepoint: Before intervention and 7 days after intervention. Method of measurement: Based on the diagnosis of the treating physician and SIRS criteria. Mashhad University of Medical Sciences Approved 2020-04-11 Ethics committee of Mashhad University of Medical Sciences Mashhad University of Medical Sciences, Faculty of Medicine, Azadi Square Mashhad Razavi Khorasan Iran (Islamic Republic of)