IRCT20200427047218N1 IRCT 2020-07-01 Shahid Beheshti University of Medical Sciences Effect of kidney transplantation in combination with N-Acetyl Cysteine and selenium Supplements on gonadal function in renal disease The effect of kidney transplant with N-Acety Cystein (NAC ) and Selenium supplement on sexual hormone profile and sexual function in end stage renal disease patinas 2020-08-22 anticipated 50 Complete https://irct.ir/trial/48139 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In order to balance random allocation of subjects between study groups, we will use randomized blocks with unequal sizes of 2 or 4 patients. List of all possible permutations will be prepared and then required number of them will be selected randomly. This will be done using appropriate piece of software or a valid websites, Blinding description: In this double blind study, similar packages will be provided for supplements and placebo; the only difference between them will be the codes written on the pack. Patients, principal investigator, residents and those involved in patients physical exam and interview will be remained blind. The only person who will be aware of the packs content, is the ward staff. She will be asked not to reveal the codes till the end of study when all required data are collected. 3 Patients with renal insufficiency who need a kidney transplant and have sexual dysfunction problems. Intervention 1: Intervention group: patients with renal insufficiency treated with renal transplantation in conjunction with N-Acetyl Cysteine 600 mg (Hakim pharmacy)and Selenium 200 µg (21st century factory)supplements daily during six month. Intervention 2: Control group: Patients with renal insufficiency undergoing renal transplantation with sexual dysfunction problems who receive the placebo instead of N-Acetyl cysteine and selenium. Yes - There is a plan to make this available What will be shared: The available information in this field include Laboratory data an complete fill up questionnaires that will be done by patients finally enable to share potentially. When: The course will start from the second half of 1399 to the end of 1399 To whom: For academic and scientific institutions will be available, also for people who are working in the industry Conditions: Any statistical analysis and use of research project information is allowed Where to obtain: Modares hospital, saadat abad ave., Saadat Abad Blvd. How to obtain: Maximum 6 months Comments: