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IRCT20180425039414N3 IRCT 2020-06-17 Esfahan University of Medical Sciences The effect of vitamin C and E in the treatment and clinical course of patients with SARS-cov2 (COVID-19) The effect of vitamin C and E in the treatment and clinical course of patients with SARS-cov2 (COVID-19) 2020-04-20 anticipated 80 Complete https://irct.ir/trial/48083 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: 80 patients with Qovid-19who had a case file in the hospital registration system and inclusion criteria, were selected available, consecutively, until the sample size was completed. The patients are then randomly assigned to the two groups of intervention and control (randomly using Block Randomization by four blocks). 2-3 SARS-cov2(COVID-19). Intervention 1: Intervention group: Includes 40 patients with COVID-19 for 5 days, hydroxychloroquine sulfate tablets with lopinavir / ritonavir tablets of 200/50 mg, 2 tablets every 12 hours, or 400 mg hydroxychloroquine diet on the first day and then 200 mg. It will be given every 12 hours. In addition to the above, 1 gram of oral vitamin C and 400 units of oral vitamin E will be prescribed daily during the patient's hospital stay. Intervention 2: Control group: Includes 40 patients with COVID-19 for 5 days, hydroxychloroquine sulfate tablets with lopinavir / ritonavir tablets of 200/50 mg, 2 tablets every 12 hours, or 400 mg hydroxychloroquine diet on the first day and then 200 mg. It will be given every 12 hours. Yes - There is a plan to make this available What will be shared: All information can be shared two months after the results are published. When: Two months after the results are published. To whom: Doctors, nurses, and infectious disease specialists Conditions: To evaluate other complementary therapies and compare their effects with existing COVID-19 therapy Where to obtain: Send email to a.hakamifard@med.mui.ac.ir How to obtain: Two months after the publication of the results, send your email to a.hakamifard@med.mui.ac.ir and write your request clearly. In this case, and finally within a month after receiving the email and the above will be answered Comments:
public Atousa Hakamifard
Alzahra hospital, Sofeh Ave.
Isfahan Iran (Islamic Republic of) ۷۳۴۶۱-۸۱۷۴۶ +98 31 3668 5555 a.hakamifard@med.mui.ac.ir Esfahan University of Medical Sciences scientific Atousa Hakamifard
Alzahra hospital, Soffeh Ave
Isfahan Iran (Islamic Republic of) ۷۳۴۶۱-۸۱۷۴۶ +98 31 3668 5555 a.hakamifard@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) 18 years of age or older Diagnosis of COVID-19 by RT PCR and CT scan of the lungs Blood oxygen levels are between 90 and 93 percent Breathing rate between 20 and 24 per minute Heart rate between 100 and 130 beats per minute 18 years no limit Both Intubation (mechanical ventilation) Shortness of breath caused by cardiogenic pulmonary edema Pregnancy and lactation Patients with end stage, lung, malignant, G6PD deficiency, diabetic ketoacidosis, cardiac arrhythmia U07.1 COVID-19, virus identified Treatment - Drugs Treatment - Drugs Intervention group: Includes 40 patients with COVID-19 for 5 days, hydroxychloroquine sulfate tablets with lopinavir / ritonavir tablets of 200/50 mg, 2 tablets every 12 hours, or 400 mg hydroxychloroquine diet on the first day and then 200 mg. It will be given every 12 hours. In addition to the above, 1 gram of oral vitamin C and 400 units of oral vitamin E will be prescribed daily during the patient's hospital stay. Control group: Includes 40 patients with COVID-19 for 5 days, hydroxychloroquine sulfate tablets with lopinavir / ritonavir tablets of 200/50 mg, 2 tablets every 12 hours, or 400 mg hydroxychloroquine diet on the first day and then 200 mg. It will be given every 12 hours. Clinical response. Timepoint: During hospitalizatio. Method of measurement: Cessation of fever, improvement of shortness of breath, reduction of cough, blood oxygenation (SaO2) and hemodynamic parameters. Mortality. Timepoint: During hospitalizatio. Method of measurement: Count the number of dead patients. Hospital stay. Timepoint: During hospitalizatio. Method of measurement: Count the number of hospital days to improve clinical symptoms. Esfahan University of Medical Sciences Approved 2020-04-16 Ethics committee of Isfahan University of Medical Sciences Isfahan University of Medical Sciences, Hezar Jarib Street. Isfahan Isfehan Iran (Islamic Republic of)