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IRCT20200509047365N1 IRCT 2020-06-02 Esfahan University of Medical Sciences Effect of L-carnitine on insulin resistance Evaluation the effect of L-carnitine on insulin resistance and prognosis of patients with ischemic stroke admitted to the Intensive Care Unit of Alzahra hospital: randomized, double blinded clinical trial 2019-04-21 anticipated 40 Complete https://irct.ir/trial/48062 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: By selecting labeled cards, "drug group" or "placebo group", Patients are randomly allocated to drug or placebo groups, Blinding description: In this double-blind study; participants, care providers, and investigators are unaware of prescribed drugs for the study groups. 3 Ischemic stroke. Intervention 1: Intervention group: L-carnitine 250 mg of Pursina Company, two tablets every 8 hours for six days orally or via nasogastric tube (NGT). Intervention 2: Control group: Placebo of Pursina Company two tablets every 8 hours for six days orally or via NGT. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Malihe Nejati
Clinical pharmacy and pharmaceutical practices department, Pharmacy faculty, Isfahan university of medical sciences, Hezarjerib St.
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 7071 nejati@pharm.mui.ac.ir Esfahan University of Medical Sciences scientific Shadi Farsaei
Clinical pharmacy and pharmaceutical practices department, Pharmacy faculty, Isfahan university of medical sciences, Hezarjerib St.
Isfahan Iran (Islamic Republic of) 8174673461 +98 31 3792 7071 farsaei@pharm.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Age of 18 years or older Diagnosis of ischemic stroke 18 years no limit Both A diagnosis of hemorrhagic stroke History of hypersensitivity to L-carnitine History of taking L-carnitine in the last month Required dialysis I63 Cerebral infarction Treatment - Drugs Treatment - Drugs Intervention group: L-carnitine 250 mg of Pursina Company, two tablets every 8 hours for six days orally or via nasogastric tube (NGT) Control group: Placebo of Pursina Company two tablets every 8 hours for six days orally or via NGT Determination and comparison of mean insulin resistance before and after intervention. Timepoint: Before intervention and 7 days after intervention. Method of measurement: Homeostatic model assessment of insulin resistance (HOMA-IR). Determination and comparison of Prognosis of two groups. Timepoint: Daily from day 1, before intervention to day 7 and 28 days after intervention. Method of measurement: Frequency of 28-day mortality and duration of mechanical ventilation, daily Glasgow Coma Scale and Sequential Organ Function Assessment scores, whether or not sepsis occurs through the intervention days based on SOFA score changes. Esfahan University of Medical Sciences Approved 2019-02-06 Ethics committee of Isfahan University of Medical sciences Department of clinical pharmacy and pharmaceutical practices, faculty of pharmacy, Isfahan University of Medical sciences, Hizar jarib street Isfahan Isfehan Iran (Islamic Republic of)