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IRCT20130228012654N2 IRCT 2020-06-02 Islamic Azad University Comparing the effect of topical Wishca, Diclofenac and Capsaicin cream in knee osteoarthritis Comparison the therapeutic effect of topical Wishca,Diclofenac and Capsaicin in patient with knee Osteoarthritis 2017-09-23 anticipated 45 Complete https://irct.ir/trial/47712 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomztion, a random sequence generated for three treatment groups. for this purpose, a point in random numbers table was selected and moving to the right, considering single digits, from numbers 1 to 3 assigned to group A: Wishca, numbers 4 to 6 to group B: Cepx and numbers 7 to 9 were assigned to group C: Diclofenac. Based on this sequence, participants entered three treatment groups. randomization unit: individual. N/A knee osteoarthritis. Intervention 1: Intervention group 1: Wishca, patients receiving WishCa herbal cream produced in IMD Company (Dr. Kamkar International Laboratory) contains the active ingredient of 7 herbs; Patients were asked to apply 1 mL of ointment 3 times a day, topically on the osteoarthritic knee. Intervention 2: Intervention group 2: Capsaicin, patients receiving Capex 0.034%, produced by Barijessence inc ; Patients were asked to apply 1 mL of ointment 3 times a day, topically on the osteoarthritic knee. Intervention 3: Control group: Diclofenac patents receiving Diclofenac Diethylammonium Salt Eq To diclofenac 1% gel produced by RAZAK Labs. Co ; Patients were asked to apply 1 mL of ointment 3 times a day, topically on the osteoarthritic knee. No - There is not a plan to make this available Justification or reason for not sharing IPD is The data would be delivered upon journal request
public Fatemeh Hosseinnezhad
00
Mashhad Iran (Islamic Republic of) 9183857838 00 hosseinnezhad.fatemeh70@gmail.com Islamic Azad University scientific Fatemeh Hosseinnezhad
sarab street,   Faculty of Medicine, Mashhad Islamic Azad University
Mashhad Iran (Islamic Republic of) 9183857838 00 hosseinnezhad.fatemeh70@gmail.com Islamic Azad University Iran (Islamic Republic of) confirmed knee osteoarthritis according to American Rheumatology Association criteria history of knee pain ages 30 to 70 knee pain on most days of >40 mm on a 100 mm VAS on the worst knee giving informed consent 30 years 70 years Both patient with other forms of arthritis (including secondary osteoarthritis, Rheumatic diseases a significant knee injury Having Low Back Pain and other referral pain to the knee History of arthroscopy in the previous 6 months, History of corticosteroid injection in the last 3 months History of knee surgery History of the knee clinical trials participation History of intra-articular injection of hyaluronic acid in the previoHistory of malignancyus 6 months open knee wound active dermatitis Infectious disease involving joints like TB or brucellosis acute psychological illness (especially depression) History of malignant neoplasm history of lower limb trauma leads to rupture of the meniscus, ligament, or capsule Patients with increased complaints and who are not satisfied with continuing medication M17 Osteoarthritis of knee Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: Wishca, patients receiving WishCa herbal cream produced in IMD Company (Dr. Kamkar International Laboratory) contains the active ingredient of 7 herbs; Patients were asked to apply 1 mL of ointment 3 times a day, topically on the osteoarthritic knee. Intervention group 2: Capsaicin, patients receiving Capex 0.034%, produced by Barijessence inc ; Patients were asked to apply 1 mL of ointment 3 times a day, topically on the osteoarthritic knee. Control group: Diclofenac patents receiving Diclofenac Diethylammonium Salt Eq To diclofenac 1% gel produced by RAZAK Labs. Co ; Patients were asked to apply 1 mL of ointment 3 times a day, topically on the osteoarthritic knee. Symptoms and function of affected knee. Timepoint: At the baseline, the end of week 1 and 4 with one week washout period. Method of measurement: KOOS questionnaire. Pain. Timepoint: At the baseline, the end of week 1 and 4 with one week washout period. Method of measurement: VAS visual analogue scale. Range of motion. Timepoint: At the baseline, the end of week 1 and 4 with one week washout period. Method of measurement: Angle measurement. Vice Chancellor of Research, Faculty of Medicine, Mashhad Islamic Azad University Approved 2017-08-23 Ethics committee of Mashhad Islamic Azad University, Faculty of Medicine Sarab street, Shahinfar faculty of medical science Mashhad Razavi Khorasan Iran (Islamic Republic of)