IRCT20150825023753N15 IRCT 2020-10-18 Shiraz University of Medical Sciences Efficacy of oral safflower oil in treatment of melasma Efficacy of oily oral product of Carthamus tinctorius in comparison with placebo on the treatment of melasma: a randomized controlled clinical trial 2020-10-11 anticipated 40 Complete https://irct.ir/trial/47588 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Random allocation software Ink is used to create blocks. Then, patients based on their allocated numbers are placed in groups A or B considering the designed table, Blinding description: In order to blind the investigator, medications were named A (oily capsule of safflower) and B (Placebo). The patients were not aware of which drug they received. The groups were also coded A and B to the statistical analyzer. 3 Melasma. Intervention 1: Intervention group: Patients in the intervention group will receive 8 grams of oily capsule containing safflower seed oil (manufactured by Barij Company) orally, daily. Also, patients in this group will use hydroquinone 4% cream (made by Pars Daroo company) every night for two hours before going to bed. Intervention 2: Control group: Patients in the placebo group will receive 8 grams of paraffin-containing capsules (made by Barij Company) orally, daily. Also, these patients will use 4% hydroquinone cream made by Pars Daroo company every night for two hours before going to bed. Yes - There is a plan to make this available What will be shared: Demographic data and the result of the clinical trial When: One year later To whom: Researchers Conditions: After publication of the extracted article of the clinical trial Where to obtain: Sending Email to the researchers How to obtain: Sending the request via the email Comments: