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IRCT20190618043923N4 IRCT 2020-05-04 Tabriz University of Medical Sciences Ozone Autohemotherapy in Covid19 Investigation the effects medical Ozone Autohemotherapy on clinical and para clinical features of patients with Covid19 2020-04-25 anticipated 20 Complete https://irct.ir/trial/47363 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: A block randomization method will be used to allocate participants to the groups with a 1:1 allocation using random allocation software (RAS). Similar sealed envelopes will be used to conceal the allocation in a sequentially numbered opaque package, Blinding description: Participants, data collection officials, those who evaluate the outcome and the person responsible for data analysis will be blinded to random allocation of participants to study groups. 2-3 Coronavirus infection. Intervention 1: Intervention group: Major Autohemotherapy with common treatments. 100 ml of the patient heparinized blood is mixed with 100 ml of ozone at a concentration of 30micro /mL O2-O3 and injected again. These injections are given 3 times a week for a total of 10 times. Intervention 2: Control group: Common treatments. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information.
public Dawood Aghamohammadi
Emam Reza hospital, Golgasht Str., Azadi Ave.
Tabriz Iran (Islamic Republic of) 5163995479 +98 41 3336 1928 daghamohamadi@yahoo.com Tabriz University of Medical Sciences scientific Dawood Aghamohammadi
Emam Reza hospital, Golgasht Str., Azadi Ave.
Tabriz Iran (Islamic Republic of) 5163995479 +98 41 3336 1928 daghamohamadi@yahoo.com Tabriz University of Medical Sciences Iran (Islamic Republic of) Being 20-60 years of age Having a positive reverse-transcriptase polymerase chain reaction test for SARS-CoV-2 Being admitted to the intensive care unit Receiving invasive mechanical ventilation that began a short time before admission or in the intensive care unit 20 years 60 years Both Patients with an anticipated survival length of fewer than 24 hours Patients with a body mass index of 35 kg/m2 and over Patients with a history of blood disorders Patients with a history of renal or liver failure or chronic obstructive pulmonary disease Pregnant or lactating women Patients who were joined in other clinical trials B34.2 Coronavirus infection, unspecified Treatment - Drugs Placebo Intervention group: Major Autohemotherapy with common treatments. 100 ml of the patient heparinized blood is mixed with 100 ml of ozone at a concentration of 30micro /mL O2-O3 and injected again. These injections are given 3 times a week for a total of 10 times. Control group: Common treatments Complete Blood cell count and diffrential count. Timepoint: Complete Blood cell count and diffrential count at the beginning of the study (before the intervention) and 7, 14 and 21 days after the start of ozone autohemotherapy. Method of measurement: Biochemical analysis. Liver function tests. Timepoint: Liver function tests at the beginning of the study (before the intervention) and 7, 14 and 21 days after the start of ozone autohemotherapy. Method of measurement: Biochemical analysis. Renal function tests. Timepoint: Renal function tests at the beginning of the study (before the intervention) and 7, 14 and 21 days after the start of ozone autohemotherapy. Method of measurement: Biochemical analysis. Mechanical ventilator weaning time. Timepoint: Mechanical ventilator weaning time during the study after the start of ozone autohemotherapy. Method of measurement: Comment by the treating physician. Tabriz University of Medical Sciences Approved 2020-04-13 Ethics committee of Tabriz University of Medical Sciences Research Vice Chancellor, Tabriz University of Medical Sciences, Daneshgah Ave. Tabriz East Azarbaijan Iran (Islamic Republic of)