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IRCT20190810044500N16 IRCT 2021-06-13 Yazd University of Medical Sciences Preparation & evaluation of Topical Rosuvastatin & Melatonin vs placebo in Patients with Mild to Moderate Plaque Psoriasis Preparation & evaluation of Topical Rosuvastatin & Melatonin vs placebo in Patients with Mild to Moderate Plaque PsoriasisØ› A Randomized Double-blinded Clinical Trial 2021-04-21 anticipated 51 Complete https://irct.ir/trial/47196 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: First, using Random allocation software (version 1.0), we generate a random sequence by a simple random allocation method. In this table, we specify from 1 to 51 and each number is assigned to an intervention group (A or B or C). The first eligible person is referred to as number 1, the second person as number 2, and so on up to 51 patients. To be blind to random allocation, patients are placed in one of the intervention groups (A or B or C) according to the table by a third person who is unaware of the interventions, Blinding description: Patients, clinical evaluators, and physicians will be blinded by the type of intervention. 2 Psoriasis. Intervention 1: Intervention group: Patients will use 5% melatonin cream twice daily for 8 weeks. Intervention 2: Intervention group: Patients will use 5% rosuvastatin cream twice daily for 8 weeks. Intervention 3: Control group: Patients will use placebo cream twice daily for 8 weeks. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information
public Fatemeh Saghafi
Professor Hesabi Blvd., Yazd Province, Yazd, Iran
yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 F.saghafi@ssu.ac.ir Yazd University of Medical Sciences scientific fatemeh saghafi
Professor Hesabi Blvd., Yazd Province, Yazd, Iran
yazd Iran (Islamic Republic of) 8915173149 +98 35 3820 3419 F.saghafi@ssu.ac.ir Yazd University of Medical Sciences Iran (Islamic Republic of) Patients 18 years and older Less than 10% body surface area (BSA) 18 years no limit Both Pregnancy Sensitivity to cream components L40 Psoriasis Treatment - Drugs Treatment - Drugs Placebo Intervention group: Patients will use 5% melatonin cream twice daily for 8 weeks Intervention group: Patients will use 5% rosuvastatin cream twice daily for 8 weeks Control group: Patients will use placebo cream twice daily for 8 weeks Psoriasis Area Severity Index. Timepoint: Weeks 0, 4, 8. Method of measurement: Score 0_72. Dermatological Sum Score (DSS). Timepoint: Weeks 0,4,8. Method of measurement: Based on a scale of 4 points (0: absent,1: mild, 2: moderate, 3: severe). Dermatology Life Quality Index (DLQI). Timepoint: weeks 0,4,8. Method of measurement: Based on the questionnaire. Yazd University of Medical Sciences Approved 2020-11-09 Ethics Commitee of Shahid Sadoughi University Medical Sciencrs Shahid Sadoughi university of medical sciences, Professor Hesabi Blvd, Yazd, Iran yazd Yazd Iran (Islamic Republic of)