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IRCT20190410043224N2 IRCT 2020-06-09 Esfahan University of Medical Sciences Evaluation of Non-Wheat gluten Diet in Chidren and Adolescents With Functional Abdominal Pain Evaluation of Non-Wheat gluten Diet in Chidren and Adolescents With Functional Abdominal Pain 2020-04-20 anticipated 60 Complete https://irct.ir/trial/47068 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Crossover, Purpose: Treatment, Randomization description: Each child with functional abdominal pain is placed in the intervention or control group using a random number table as soon as the doctor diagnoses it.In this way, the even members are in the intervention group and the odd members are in the control group. This process continues until the sample size is complete. 2-3 Functional abdominal pain. Intervention 1: Intervention group: First, a gluten-free diet is given for 3 weeks. Then 3 weeks of regular diet as a wash out period and then 3 weeks of gluten-containing diet. Intervention 2: Control group: First, a gluten-free diet is given for 3 weeks, then a normal diet for 3 weeks, and then a gluten-free diet for 3 weeks. Yes - There is a plan to make this available What will be shared: Data about main outcome When: 6 months after publication To whom: Everybody Conditions: For research and clinical practice Where to obtain: peiman94157@gmail.com How to obtain: Please contact me via Email address. I will send you the data after one week. Comments:

public Peiman Nasri

Imam Hossein Hospital, Imam Khomeini Avenue, Isfahan

Isfahan Iran (Islamic Republic of) ۸۱۹۵۱۶۳۳۸۱ +98 31 3386 7436 peiman94157@gmail.com Esfahan University of Medical Sciences scientific Peiman Nasri

Imam Hossein Hospital, Imam Khomeini Avenue, Isfahan

Isfahan Iran (Islamic Republic of) ۸۱۹۵۱۶۳۳۸۱ +98 31 3386 7436 peiman94157@gmail.com Esfahan University of Medical Sciences Iran (Islamic Republic of) Children with functional abdominal pain according to the criteria of Rome 4 in the ages of 12 to 18 years, referred to the subspecialty gastroenterology clinics of Isfahan University of Medical Sciences with the conditions.. ...... Do not take steroids or nonsteroidal anti-inflammatory drugs or any other medication for 2 weeks before endoscopic examination Patients who are not on medication(Do not take steroids / antacids / proton pump inhibitors / probiotics / nonsteroidal anti-inflammatory drugs / antidepressants and antipsychotics) Patients who have not been on a gluten-free / gluten-free diet for the past 6 months Lack of sensitivity to wheat Absence of other organic diseases of the gastrointestinal tract (celiac disease, inflammatory bowel disease .......) Absence of abdominal surgery (intestinal resection) Absence of diseases, infectious / diabetes mellitus / systemic autoimmune / immunodeficiency / psychological disorders No previous anaphylactic reaction attacks Negative Anti endomysial Ab test 12 years 18 years Both Children with abdominal pain with organic causes. Treatment - Other Treatment - Other Intervention group: First, a gluten-free diet is given for 3 weeks. Then 3 weeks of regular diet as a wash out period and then 3 weeks of gluten-containing diet. Control group: First, a gluten-free diet is given for 3 weeks, then a normal diet for 3 weeks, and then a gluten-free diet for 3 weeks. Functional abdominal pain. Timepoint: In both groups before the intervention and three weeks after the intervention and three weeks after the Wash out. Method of measurement: Check list and questionaire. In each stage of filling out the checklist, "In addition to abdominal pain, variables of diarrhea, bloating, body pain, limb pain, anxiety, headache, and feeling unwell are also evaluated.". Timepoint: In both groups before the intervention and three weeks after the intervention and three weeks after Wash out. Method of measurement: Checklist and questionnaire. Esfahan University of Medical Sciences Approved 2019-04-12 Ethics committee of Isfahan University of Medical Sciences Ethics committee of Isfahan University of Medical Sciences, Isfahan University of medical sciences, Hezarjarib Ave, Isfahan Isfehan Iran (Islamic Republic of)