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IRCT20200406046967N1 IRCT 2020-04-10 Shiraz University of Medical Sciences Effect of Colchicine in treatment of chronic urticaria Evaluation of the effect of colchicine on the antithyroid antibody titer in chronic urticaria patient. 2020-05-04 anticipated 50 Complete https://irct.ir/trial/46991 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: This study is based on a Random number table. In this study, table numbers are read from above and to the right. Couples' numbers are for the first group (intervention) and individual numbers are for the second group (control), Blinding description: Patients know that they are participating in the study and have entered the study consciously and with prior written consent, but do not know exactly which group they are in. he main researchers of the study are unaware of the type of medication used for each patient and how the patients are assigned to the groups and which group each patient is in. Data collection and follow-up officials are unaware of the type of medication used for each patient and how the patients are assigned to the groups and which group each patient is in. 3 Positive Autoantibody Chronic Urticaria. Intervention 1: Intervention group: "The first intervention group of Fexofenadine tablets 120 mg once daily for 3 months from Saha Pharmaceuticals, Doxepin tablets 10 mg once daily for 3 months from Razak Pharmaceuticals and Colchicine tablets 1 mg once daily for 3 months from Modava Pharmaceuticals". Intervention 2: Intervention group: "The second intervention group of Fexofenadine tablets 120 mg once daily for 3 months from Saha Pharmaceuticals, Doxepin tablets 10 mg once daily for 3 months from Razak Pharmaceuticals" ;. Yes - There is a plan to make this available What will be shared: All data can be shared after people have not been identified. When: Starting the access period 3 months after the publication of the results To whom: It will be available for researchers worker in academic and scientific institutions. Conditions: they can provide jobs, university and reason of using data and articles. Where to obtain: Email adress How to obtain: 2 days Comments:
public Masroor Babaeian
3rd floor, Niki 2 building, Ansar 1 Ave, besat Blvd
Shiraz Iran (Islamic Republic of) 7184684189 +98 71 3649 9543 masroor.babaeian@yahoo.com Shiraz University of Medical Sciences scientific Masroor Babaeian
3rd floor., Niki 2 building ., 1 Ansar Ave ., besat Blvd
Shiraz Iran (Islamic Republic of) 7184684189 +98 71 3649 9543 Masroor.babaeian@yahoo.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Patients with chronic urticaria in the age range of 20 to 70 years 20 years 70 years Both pregnant and lactating females Patients with Physical Urticaria and Vasculitis Urticaria Patients with Colchicine-induced drug side effects L50.1 Idiopathic urticaria Treatment - Drugs Treatment - Drugs Intervention group: "The first intervention group of Fexofenadine tablets 120 mg once daily for 3 months from Saha Pharmaceuticals, Doxepin tablets 10 mg once daily for 3 months from Razak Pharmaceuticals and Colchicine tablets 1 mg once daily for 3 months from Modava Pharmaceuticals" Intervention group: "The second intervention group of Fexofenadine tablets 120 mg once daily for 3 months from Saha Pharmaceuticals, Doxepin tablets 10 mg once daily for 3 months from Razak Pharmaceuticals" ; "Percentage of people with chronic urticaria who have autoimmune thyroiditis". Timepoint: "Measurement of thyroid autoantibodies at the beginning of the study (before the intervention) and 3 months after taking colchicine". Method of measurement: "Peripheral blood sample". " The urticaria score in the Urticaria Activity Score 7 questionnaire". Timepoint: " Comparison of the average total score of the Urticaria Activity Score 7 questionnaire in the study groups at the beginning of the study and 3 months after taking colchicine". Method of measurement: " Urticaria Activity Score 7 questionnaire". "The urticaria score in the Chronic Urticaria Quality of Life questionnaire". Timepoint: Comparison of the average total score of the Chronic Urticaria Quality of Life questionnaire in the study groups at the beginning of the study and 3 months after taking colchicine". Method of measurement: "Chronic Urticaria Quality of Life questionnaire". Shiraz University of Medical Sciences Approved 2019-09-08 Ethics committee of Shiraz University of Medical Sciences 3rd floor., Niki 2 building., Ansar Ave., besat Blvd Shiraz Fars Iran (Islamic Republic of)