IRCT20081027001411N3 IRCT 2020-06-01 Tehran University of Medical Sciences Effect of Prednisolone on treatment of COVID-19 Study of Prednisolone effects on treatment and clinical symptoms and laboratory signs of Iranian COVID-19 patients: a clinical trial study 2020-03-29 anticipated 60 Complete https://irct.ir/trial/46975 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: This study will be carried out on 60 hospitalized ‎COVID-19 patients. Patients randomly divided into two groups: control group and treatment group ‎which received 0.5mg/kg prednisolone in three divided doses up to 30 mg per day for 5-7 days. Clinical signs of patient including ‎heart rate, blood pressure ‎ body temperature, O2 saturation, CT scan findings, laboratory tests result ‎‎(CBC, ESR, CRP, Ferritin, Troponin, D-dimer) will be recorded before treatment ‎‎and at day 8 and day 14). In addition, Patients' mortality rates, length of hospitalization, and the need for mechanical ventilation and intubation are recorded in two groups of intervention and control, Randomization description: Block Balanced Randomization Method will be used. Patients will allocate to two groups with Block Balanced Randomization Method. The size of each random block is 2, and patients will be allocated equally to the two intervention groups, Blinding description: In this study patients don't know which group of patients will use the ‎medicine. Physician and clinicians team know about the drug and group who use the drug.‎. 2 COVID-19 disease. Intervention 1: Intervention group: Patients hospitalized with COVID-19 disease who in addition to their standard treatment will received 0.5mg/kg prednisolone in three divided doses up to 30 mg per day for 5-7 days. Intervention 2: Control group: Patients hospitalized with COVID-19 disease who are received standard treatment. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no more information