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IRCT20171030037093N35 IRCT 2020-04-11 Esfahan University of Medical Sciences Effect of Xylitol nasal spray in treatment of chronic rhinosinusitis Evaluation of the effect of Xylitol nasal spray in treatment of patients with chronic rhinosinusitis 2020-04-07 anticipated 30 Complete https://irct.ir/trial/46638 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The sample was randomly divided into two groups of 15 patients. Each envelope containing one of the two labels A and B represented one of the intervention groups, Blinding description: For the purpose of blinding, neither the patients nor the researchers were aware of the type of treatment each group received until the completion of the study. The treatments were divided into two groups as closed packages with codes A and B that were assigned to group A packages containing code A and group B packages containing code B. 2-3 Rhinosinusitis. Intervention 1: Intervention group: xylitol nasal spray intervention group is given two puffs every 8 hours for 30 days. Intervention 2: Control group: The second group, or placebo, received normal saline two puffs every 8 hours for 30 days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is I will decide until finishing the study
public Ahmad Rezaeian
Alzahra hospital
Isfahan Iran (Islamic Republic of) 7346181746 +98 31 3556 5175 ahmadrezaeian@med.mui.ac.ir Esfahan University of Medical Sciences scientific Ahmad Rezaeian
Alzahra hospital
Isfahan Iran (Islamic Republic of) 7346181746 +98 31 3556 5175 ahmadrezaeian@med.mui.ac.ir Esfahan University of Medical Sciences Iran (Islamic Republic of) Patients with chronic rhinosinusitis Age over 18 years They had previously undergone sinus endoscopy and now need only non-surgical treatments. 18 years no limit Both Patients who have a history of allergic rhinitis, asthma, immunodeficiency, cystic fibrosis, primary pulmonary dyskinesia, active bacterial or fungal infection and need antibiotics or antifungals Patients who are unsatisfied with non-surgical treatment or want to have surgery again for any reason Have a history of head and neck radiation therapy Now be a smoker Pregnant people Have granulomatous disease J32.9 Chronic sinusitis, unspecified Treatment - Drugs Treatment - Drugs Intervention group: xylitol nasal spray intervention group is given two puffs every 8 hours for 30 days. Control group: The second group, or placebo, received normal saline two puffs every 8 hours for 30 days. Lund Kennedy Score. Timepoint: Before and after the study. Method of measurement: Lund Kennedy questionnaire. SNOT 22 (Sino-nasal Outcome Test) score. Timepoint: Before the intervention and 30 days after the intervention. Method of measurement: SNOT 22 (Sino-nasal Outcome Test). Severe pain when pressing on the sinuses. Timepoint: Before and after the study. Method of measurement: VAS (Visual Analog Scale) questionnaire. Esfahan University of Medical Sciences Approved 2020-01-14 Ethics Committee of Isfahan University of Medical Sciences Isfahn University of Medical Sciences, Hezar jarib st, Isfahan Isfahan Isfehan Iran (Islamic Republic of)