IRCT20200307046712N1 IRCT 2020-04-06 Alborz University of Medical Science Evaluation of the effect of vitamin B1 and B6 in manic patients Evaluation of the effect of vitamin B1 and B6 as an adjunct therapy to improve the symptoms of mania phase of bipolar disorder type I; in a double-blind and placebo-controlled clinical trial 2020-03-14 anticipated 67 Complete https://irct.ir/trial/46471 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Supportive, Randomization description: Method of randomization: simple Unit of randomization: individual Tools used in randomization: table of random numbers Randomization will be done in the absence of patients' sight, Blinding description: According to double-blinding, all the groups of patients will take their drugs without any knowledge about types of them. Also, the patients' nurse will give these drugs to the them according to the randomization the physician has made, without consciousness about types of them. 3 Bipolar disorder. Intervention 1: First intervention group: This group will take 1.5 mg/kg vitamin B1 plus 900 mg lithium bicarbonate. Intervention 2: Second international group: This group will take 0.6 mg/kg vitamin B6 plus 900 mg lithium bicarbonate. Intervention 3: Control group: This group will take one placebo plus 900 mg lithium bicarbonate each day. The placebo will be made in the laboratory of the Alborz University of Medical Science. No - There is not a plan to make this available Justification or reason for not sharing IPD is The data won,t be released until the publication of the study.