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IRCT20130812014333N142 IRCT 2020-03-17 Kermanshah University of Medical Sciences Comparative study of the effectiveness of fentanyl with and without nitroglycerine spray on hemodynamic response due to laryngoscopy and endotracheal intubation Comparative study of the effectiveness of fentanyl with and without nitroglycerine spray on hemodynamic response due to laryngoscopy and endotracheal intubation 2020-04-07 anticipated 40 Complete https://irct.ir/trial/46343 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Using the random number table, patients are divided into three groups of 20. Each patient is assigned a 4-digit code based on the random number table, Based on the right number of patients code, the patients are divided into two groups. Patients whose last digit is 0, 2, 4, 6, 8 will be assigned to the first intervention group and patients whose last digit is 1,3,5, 7, 9 will be assigned to the second intervention group, Blinding description: The data analyzer was kept blind to the allocation of study groups. 2-3 General anesthesia. Intervention 1: The first intervention group will receive fentanyl 2 µg / kg. Intervention 2: The second intervention group will receive two puffs of nitroglycerin spray (400 micrograms) with fentanyl 2 μg / kg for 5 min before tracheal intubation (anesthesia induction) and laryngoscopy intravenously for 30 seconds. Yes - There is a plan to make this available What will be shared: The main outcomes of the study will be shared. When: 6 months To whom: If requested, results will be made available to other academic researchers Conditions: Collected data is confidential and will not be shared with anyone else Where to obtain: To receive the documentation, email send for update manager How to obtain: In a 15-day period, the documents will be sent e-mail Comments:
public Javad Nazari
Emam Reza Hospital, Parastar Boulevard
Kermanshah Iran (Islamic Republic of) 6715847141 +98 83 3427 6306 sajad.nazari90@yahoo.com Kermanshah University of Medical Sciences scientific Dr. javad Aminisaman
Emam Reza Hospital, Parastar Boulevard
Kermanshah Iran (Islamic Republic of) 6715847141 +98 83 3427 6306 Aminisaman399@Gmail.com Kermanshah University of Medical Sciences Iran (Islamic Republic of) Age between 20-60 years No history of heart disease or stroke, high blood pressure, and drug use and addiction accidentally 20 years 60 years Both Patients who have had laryngoscopy more than once Patients with diabetes I46.9 Cardiac arrest, cause unspecified Treatment - Drugs Treatment - Drugs The first intervention group will receive fentanyl 2 µg / kg The second intervention group will receive two puffs of nitroglycerin spray (400 micrograms) with fentanyl 2 μg / kg for 5 min before tracheal intubation (anesthesia induction) and laryngoscopy intravenously for 30 seconds. Blood pressure. Timepoint: Before starting the study, before laryngoscopy and intubation and at 10 and 1,3,5,7 minutes, after laryngoscopy and endotracheal intubation. Method of measurement: Using a barometer. Heart beat. Timepoint: Before starting the study, before laryngoscopy and intubation and at 10 and 1,3,5,7 minutes, after laryngoscopy and endotracheal intubation. Method of measurement: Using the pacemaker. Kermanshah University of Medical Sciences Approved 2020-03-02 Ethics committee of Kermanshah University of Medical Sciences Building No.2, Shahid Beheshti, Vice Chancellor for Research Affairs, Kermanshah University of Medical Sciences Kermanshah Kermanshah Iran (Islamic Republic of)