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IRCT201108044339N6 IRCT 2011-09-22 Yazd University of Medical Sciences natural frozen – thawed embryo transfer cycles IVF effect of progesterone in natural frozen – thawed embryo transfer cycles 2011-03-01 anticipated 109 Complete https://irct.ir/trial/4620 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients were randomized to either group in a ratio of 1:1 by means of computer-generated random numbers on the day of participation. Group selection and randomization were performed by a nurse not involved in the study, by using opaque sealed envelopes. Both the patients and the clinicians were aware of the allocated arm. 2 female infertility. Intervention 1: On the second or third days of the menstrual cycle, all patients underwent transvaginal ultrasounds and serum hormone analysis for FSH. Then, a vaginal ultrasonographic examination was performed on cycle days 10 and repeated as necessary. Final oocyte maturation was achieved by intramuscular (IM) administration of 10000 IU of hCG (Pregnyl, Daropakhsh, Iran) when an endometrial thickness of 8 mm or more and a follicle of 18 mm were present on the ultrasound. On the day of the hCG administration, we measured serum estradiol‚ progesterone and LH levels.The progesterone group received 100mg/day of progesterone (Aburaihan Pharmaceutical Co., Tehran, Iran) IM, that began 36 hours after the hCG administration and continued until ten weeks of gestation if pregnancy occurred. In both groups, cryopreserved embryo transfer was performed with a Cook catheter (Cook Ireland Ltd.) five days after hCG administration. Serum β-hCG level was measured 14 days after the transfer. Intervention 2: In control group :On the second or third days of the menstrual cycle, all patients underwent transvaginal ultrasounds and serum hormone analysis for FSH. Then, a vaginal ultrasonographic examination was performed on cycle days 10 and repeated as necessary. Final oocyte maturation was achieved by intramuscular (IM) administration of 10000 IU of hCG (Pregnyl, Daropakhsh, Iran) when an endometrial thickness of 8 mm or more and a follicle of 18 mm were present on the ultrasound. On the day of the hCG administration, we measured serum estradiol‚ progesterone and LH levels.Control patients received no progesterone. In both groups, cryopreserved embryo transfer was performed with a Cook catheter (Cook Ireland Ltd.) five days after hCG administration. Serum β-hCG level was measured 14 days after the transfer. https://www.ijfs.ir/article_45164.html Abstract Background: The transfer of cryopreserved embryos can be timed with ovulation in a natural cycle or after artificially preparing the endometrium with exogenous hormones. Progesterone is essential for the secretory transformation of the endometrium that permits implantation as well as maintenance of early pregnancy. The purpose of this study is to assess the effect of luteal phase supplementation on pregnancy rates in natural frozen-thawed cycles. Materials and Methods: The study was designed as a prospective randomized clinical trial of 102 women who underwent embryo transfers in natural cycles. The women in the interventional group (n=51) received intra muscular (IM) progesterone 50 mg twice a day starting from 36 hours after hCG administration. The control group (n=51) did not receive any progesterone support. Results: There were no significant differences in demographic characteristics between the groups and no statistically significant differences were observed between study and control groups in clinical pregnancy rate (33.3% vs. 27.5%, p=0.66). There were no differences in implantation rate or spontaneous abortion rate. Conclusion: Our results suggest that luteal phase support does not affect clinical pregnancy rates in natural frozen-thawed embryo transfer cycles (Registration Number: IRCT201108044339N6). Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is Due to the privacy of patients
public Dr Mozhgan Rahsepar
Yazd research and clinical center for infertility, Booali Street, Safaieh, Yazd
Yazd Iran (Islamic Republic of) 8916877391 +98 35 1824 7085 drrahsepar@hotmail.com Yazd University of Medical Sciences scientific Dr Maryam Eftekhar
Yazd research and clinical center for infertility, Booali Street, Safaieh, Yazd
Yazd Iran (Islamic Republic of) 8916877391 +98 35 1824 7085 eftekharmaryam@yahoo.com Yazd University of Medical Sciences Iran (Islamic Republic of) cryop reserved embryos after conventional in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) maternal age of 20-40 years (on the day of embryo freezing) regular menstrual cycle of 25-35 days body mass index of 20-27 kg/m2 20 years 40 years Female the use of testicular sperm for ICSI (ejaculated sperm only) basal follicle stimulating hormone stage III-IV endometriosis polycystic ovarian syndrome (PCOS) N97 female infertility Treatment - Drugs Treatment - Drugs On the second or third days of the menstrual cycle, all patients underwent transvaginal ultrasounds and serum hormone analysis for FSH. Then, a vaginal ultrasonographic examination was performed on cycle days 10 and repeated as necessary. Final oocyte maturation was achieved by intramuscular (IM) administration of 10000 IU of hCG (Pregnyl, Daropakhsh, Iran) when an endometrial thickness of 8 mm or more and a follicle of 18 mm were present on the ultrasound. On the day of the hCG administration, we measured serum estradiol‚ progesterone and LH levels.The progesterone group received 100mg/day of progesterone (Aburaihan Pharmaceutical Co., Tehran, Iran) IM, that began 36 hours after the hCG administration and continued until ten weeks of gestation if pregnancy occurred. In both groups, cryopreserved embryo transfer was performed with a Cook catheter (Cook Ireland Ltd.) five days after hCG administration. Serum β-hCG level was measured 14 days after the transfer. In control group :On the second or third days of the menstrual cycle, all patients underwent transvaginal ultrasounds and serum hormone analysis for FSH. Then, a vaginal ultrasonographic examination was performed on cycle days 10 and repeated as necessary. Final oocyte maturation was achieved by intramuscular (IM) administration of 10000 IU of hCG (Pregnyl, Daropakhsh, Iran) when an endometrial thickness of 8 mm or more and a follicle of 18 mm were present on the ultrasound. On the day of the hCG administration, we measured serum estradiol‚ progesterone and LH levels.Control patients received no progesterone. In both groups, cryopreserved embryo transfer was performed with a Cook catheter (Cook Ireland Ltd.) five days after hCG administration. Serum β-hCG level was measured 14 days after the transfer. Chemical pregnancy. Timepoint: 14 days after embryo transfer. Method of measurement: BHCG TEST. Clinical pregnancy. Timepoint: 4-5 weeks after embryo transfer. Method of measurement: Obestetrics sonography. Implantation rates. Timepoint: Five weeks after embryo transfer. Method of measurement: The number of pregnancy sacs divided by the number of transferred embryos multiplied by 100. Clinical abortion. Timepoint: before20 weeks of gestation. Method of measurement: as clinically. Yazd University of Medical Sciences Approved 2011-06-20 Yazd research and clinical center for infertility Yazd research and clinical center for infertility, Booali Street, Safaieh, Yazd Yazd Yazd Iran (Islamic Republic of)