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IRCT20200217046520N1 IRCT 2020-03-19 Shahid Beheshti University of Medical Sciences Cardioprotective Effect of Metformin on the level of micro RNAs, mir-222, mir-195, mir-21a, in type 1 diabetes patients Cardioprotective Effect of Metformin on the level of micro RNAs, mir-222, mir-195, mir-21a, in type 1 diabetes patients 2020-05-09 anticipated 28 Complete https://irct.ir/trial/46037 interventional Randomization: N/A, Blinding: Not blinded, Placebo: Not used, Assignment: Single, Purpose: Prevention. 2 Condition 1: Type 1 diabetes. Condition 2: Cardiovascular disease. Intervention group: 28 Patients 19-45 years old with type 1 diabetes referred to Loghman Hospital Endocrine Clinic. Plasma levels of miR-222, miR-195, miR-21a are first measured, then patients will be treated with metformin for 12 weeks, and then the plasma levels of the above microRNAs will be measured again. SPSS software version 24 is used and paired t-test will be used. P <0.05 was considered as the level of statistical significance. No - There is not a plan to make this available Justification or reason for not sharing IPD is No more information
public Mina Moghtaderi
Alzahra Dormitory, Niyayesh Pardis, East Niyayesh Highway
Tehran Iran (Islamic Republic of) 1996835119 +98 21 8877 0065 Minamoghtaderi@yahoo.com Shahid Beheshti University of Medical Sciences scientific Mina Moghtaderi
Alzahra Dormitory, Niyayesh Pardis, East Niyayesh Highway
Tehran Iran (Islamic Republic of) 1996835119 +98 21 8877 0065 Minamoghtaderi@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) age 19 to 45 years insulin-treated for the past three months the patient's blood sugar has been controlled HbA1c ranged from 6/5 to 7/5 lack of cardiovascular disease it's been 5 years since diabetes informed consent 19 years 45 years Both pregnancy or pregnancy intent in the near future Kidney failure (creatinine equal to or greater than 1/3) history of cardiovascular disease history of intraocular injection Glycated haemoglobin greater than 7/5 Treatment - Drugs Intervention group: 28 Patients 19-45 years old with type 1 diabetes referred to Loghman Hospital Endocrine Clinic. Plasma levels of miR-222, miR-195, miR-21a are first measured, then patients will be treated with metformin for 12 weeks, and then the plasma levels of the above microRNAs will be measured again. SPSS software version 24 is used and paired t-test will be used. P <0.05 was considered as the level of statistical significance Plasma levels of micro RNA 222 before and after metformin administration. Timepoint: Plasma level of micro RNA 222 at baseline and 12 weeks after metformin administration. Method of measurement: blood test. Plasma levels of micro RNA 195 before and after metformin administration. Timepoint: Plasma level of micro RNA 195 at baseline and 12 weeks after metformin administration. Method of measurement: blood test. Plasma levels of micro RNA 21a before and after metformin administration. Timepoint: Plasma level of micro RNA 21a at baseline and 12 weeks after metformin administration. Method of measurement: blood test. Shahid Beheshti University of Medical Sciences Approved 2019-04-30 Ethics committee of Shahid Beheshti University of Medical Sciences School of Medicine, Koodakyar St. Danshjoo Blv, Velenjak, Shahid Chamran Highway, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)