IRCT20190128042525N4 IRCT 2020-11-02 Rafsanjan University of Medical Sciences The effect of ostrich oil on treatment and quality of life of patients with chronic anal fissure: a randomized, double-blind clinical trial study The effect of ostrich oil on treatment and quality of life of patients with chronic anal fissure: a randomized, double-blind clinical trial study 2020-06-20 anticipated 146 Complete https://irct.ir/trial/45759 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Patients will be divided into two groups (group one and two) using random numbers' table (simple randomization method), Blinding description: This is a double-blind study. The drugs will be placed in the same and encoded cans, so the patient, doctor and outcome assessor will not be informed about type of prescribed drug. Coding won't be done by principal investigator and won't have access to the coding informations. 3 chronic anal fissure. Intervention 1: Intervention group: 100 g container contained Glyceryl trinitrate 0.2% -Ostrich oil 50% ointment will be prescribed for the patients. These drugs will be manufactured by Pasargad Rafsanjan Pharmacy. For their formulation 60 ml ostrich oil containers from Iranian cooperative Kesht Va Sanat Misagh, Kesht Ati company under the brand name Mika will be purchased. After making drugs patients will apply approximately 2 cm of it, topically on the anal area every 12 hours. The maximum treatment period will be 12 weeks. Intervention 2: Control group: 100 g container concluded 0.2% Glyceryl trinitrate ointment will be prescribed. approximately 2 cm of it will be applied topically on the anal area every 12 hours. The maximum treatment period will be 12 weeks. The container ingredients will be produced by Pasargad Pharmacy in Rafsanjan. No - There is not a plan to make this available Justification or reason for not sharing IPD is There is no further information