]>
IRCT20200205046380N1 IRCT 2020-03-16 Shahid Beheshti University of Medical Sciences Comparison of the effect of 5% minoxidil and topical epinephrine on the prevention of chemotherapy-induced hair loss in patients with breast cancer compared to the control group (placebo recipients) in 1398-1399 Comparison of the effect of 5% minoxidil and topical epinephrine on the prevention of chemotherapy-induced hair loss in patients with breast cancer compared to the control group (placebo recipients) 2019-12-22 anticipated 63 Complete https://irct.ir/trial/45633 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients will be divided into three blocks (A, B, and C) by block randmoization. Each block will contain 21 patients. A random allocation software will determine which patients go into which block. Then the three interventions including 5% minoxidil, topical epinephrine, and placebo will randomly be assigned to blocks A, B, or C, Blinding description: In this study, the principle investigator, all the participants, and the data analyzer will be blinded. 3 Chemotherapy-induced hair loss. Intervention 1: The first intervention group will receive 1 ml of 5% minoxidil prepared by Shahid Beheshti Pharmacology Group twice a day. Intervention 2: The second intervention group will receive 1 ml of topical epinephrine solution prepared by Shahid Beheshti Pharmacology Group twice a day. Intervention 3: The third intervention group will receive 1 ml of alcohol (placebo) prepared by Shahid Beheshti Pharmacology Group twice a day. Yes - There is a plan to make this available What will be shared: Information about the timing of diagnosis of breast cancer, the stage of the disease, the time of first episode of chemotherapy, the intervals of chemotherapy, the type of medication used by the patient, the side effects of the drug, and the analysis of trichoscopic data (with FotoFinder device). When: The data can be accessed after the publication of the results To whom: People working in academic and scientific institutions Conditions: Data can only be used to improve individuals' disease condition. Where to obtain: Dr. Khatere Zahedi 00989132154819 khaterezahedi4819@gmail.com How to obtain: Request via email with complete identification data of the individual, the institution he/she works in, thorough explanation of the reason of the request. Data can be accessed after investigation of the responsible agent. Comments:
public Khetere Zahedi
No. 3, Sahand Tower, Vanak Park Complex, Alikhani Blvd., South Shiraz Ave., Kordestan St., Tehran, Iran
Tehran Iran (Islamic Republic of) 1436943415 002188045103 khaterezahedi4819@gmail.com Shahid Beheshti University of Medical Sciences scientific Khatere Zahedi
No. 3, Sahand Tower, Vanak Park Complex, Alikhani Blvd., South Shiraz Ave., Kordestan St., Tehran, Iran
Tehran Iran (Islamic Republic of) 14369-43415 +98 21 8804 5103 khaterezahedi@sbmu.ac.ir Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Patients with breast cancer referred to Shohadaye Tajrish Hospital for chemotherapy including adriamycin, cyclophosphamide, and taxol in 2020-2021 Informed consent to participate in the study no limit no limit Female Presence of metastasis Presence of inflammatory scalp diseases Patients with other causes of hair loss including telogen effluvium, lichen planopilaris, and discoid lupus erythematosus Pregnant or lactating women Prevention Prevention Prevention The first intervention group will receive 1 ml of 5% minoxidil prepared by Shahid Beheshti Pharmacology Group twice a day. The second intervention group will receive 1 ml of topical epinephrine solution prepared by Shahid Beheshti Pharmacology Group twice a day. The third intervention group will receive 1 ml of alcohol (placebo) prepared by Shahid Beheshti Pharmacology Group twice a day. The evaluation of anagen hair count in trichoscopic findings of patients. Timepoint: The first time, the second or third time, the last time and one month after chemotherapy. Method of measurement: FotoFinder device. Shahid Beheshti University of Medical Sciences Approved 2019-12-17 Ethics Committee of Shahid Beheshti University of Medical Sciences Bldg No.2 SBUMS, Arabi Ave, Daneshjoo Blvd, Velenjak, Tehran, Iran Tehran Tehran Iran (Islamic Republic of)