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IRCT20191226045897N1 IRCT 2020-02-22 Babol University of Medical Sciences Compare intense hydration and fluid standard therapy before and after of ERCP in the prevention of post ERCP pancreatitis TO compare intense hydration and fluid standard therapy before and after of ERCP in the prevention of post ERCP pancreatitis 2018-05-01 anticipated 160 Complete https://irct.ir/trial/45342 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: These patients were randomly divided into two groups of 80 aggressive fluid therapy before and after ERCP and standard fluid therapy before and after ERCP. N/A Acute Pancreatitis. Intervention 1: Intervention group: Ringer's lactate serum was infused at a rate 1.5 times the standard limit of 4.5 cc / h before ERCP (approximately 3200 cc over 12 h with a mean weight of 60 kg) and at and after this rate. will continue. Intervention 2: Control group: During and after the liquid ERCP second group received standard treatment (/ 5CC / kg / hr1 to 12 hours later). No - There is not a plan to make this available Justification or reason for not sharing IPD is -

public Dr. Bahareh Enjilala

Babol University of Medical Sciences; Ganjafrooz Street; Babol; Iran

Babol Iran (Islamic Republic of) 4716681451 +98 11 3223 8301 h.abedi@mubabol.ac.ir Babol University of Medical Sciences scientific Dr. Sayed Hassan Abedi

Babol University of Medical Sciences; Ganjafrooz street; Babol; Iran

Babol Iran (Islamic Republic of) 4716681451 +98 11 3223 8301 h.abedi@mubabol.ac.ir Babol University of Medical Sciences Iran (Islamic Republic of) All patients over 18 years who were referred to hospital for ERCP. Patients disorders in liver function tests or had extrahepatic cholestasis. 18 years 70 years Both History of PEP and Pancreatitis with Other Pancreatic Risk Factors and Diseases Heart Failure IBD NSAID Allergy Coagulation Disorders Chronic renal failure Current hypotension (eg septic shock) Severe liver failure Respiratory failure Pregnancy Hyponatremia or Hypnothermia Edema or ascites Using high-risk outside the stone during the ERCP procedure k85.8 Other Acute Pancreatitis Prevention Prevention Intervention group: Ringer's lactate serum was infused at a rate 1.5 times the standard limit of 4.5 cc / h before ERCP (approximately 3200 cc over 12 h with a mean weight of 60 kg) and at and after this rate. will continue. Control group: During and after the liquid ERCP second group received standard treatment (/ 5CC / kg / hr1 to 12 hours later). Pancreatitis. Timepoint: 24 hours after ERCP. Method of measurement: Amylase serum, Patient's symptoms(nausea, vomiting and abdominal pain). Babol University of Medical Sciences Approved 2018-05-01 Ethics committee of Babol University of Medical Sciences Babol University of Medical Sciences, Ganjafrooz Street, Babol, Mazandaran, Iran Babol Mazandaran Iran (Islamic Republic of)