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IRCT20180520039739N4 IRCT 2020-02-17 Esfahan University of Medical Sciences Treatment of pleural effusion by albumin and lasix Evaluation of the use of albumin add-on therapy to loop diuretic for the management of pleural effusion in mechanically ventilated ill children 2020-01-30 anticipated 50 Complete https://irct.ir/trial/45338 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Simple randomization (random number table): even numbers will be allocated to control group (treatment by lasix) and odds numbers will be allocated to intervention group (treatment by Lasix and albumin), Blinding description: The patients and evaluator of the outcomes are not aware of the kind of drugs and drugs will be provided by the researcher and will be given to the nurses for usage. 3 Pleural effusion. Intervention 1: Control group: treatment with furosemide (2 mg/kg; Aburaihan Company; Iran) plus 5 ml/kg of saline 0.9% as placebo for 3 days. Intervention 2: Intervention group: 1 gr/kg albumin 20% (5 ml/kg; Alborzdarou; Iran) plus furosemide (2 mg/kg; Aburaihan Company; Iran) for three days. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Mohammadreza Habibzadeh
Hezarjerib
Esfahan Iran (Islamic Republic of) ندارد +98 913 389 1027 gsmhabibzadeh@yahoo.com Esfahan University of Medical Sciences scientific Mohammadreza Habibzadeh
Hezarjerib
Esfahan Iran (Islamic Republic of) ندارد +98 913 389 1027 gsmhabibzadeh@yahoo.com Esfahan University of Medical Sciences Iran (Islamic Republic of) ICU-admitted children Under mechanical ventilation Diagnosis of pleural effusion Age range of 1-12 years old Systolic blood pressure above 100 mmHg Serum albumin levels of less than 2.5 mg/dl 1 year 12 years Both J90 Pleural effusion, not elsewhere classified Treatment - Drugs Treatment - Drugs Control group: treatment with furosemide (2 mg/kg; Aburaihan Company; Iran) plus 5 ml/kg of saline 0.9% as placebo for 3 days Intervention group: 1 gr/kg albumin 20% (5 ml/kg; Alborzdarou; Iran) plus furosemide (2 mg/kg; Aburaihan Company; Iran) for three days Volume of pleural effusion. Timepoint: Every day up to 3 days. Method of measurement: FAST sonography. Esfahan University of Medical Sciences Approved 2020-01-08 Ethics committee of Esfahan University of Medical Sciences Esfahan University of Medical Sciences, Hezarjerib street Esfahan Isfehan Iran (Islamic Republic of)