IRCT20140107016117N5 IRCT 2020-02-01 Tabriz University of Medical Sciences Effect of oral clonidine on hemodynamics and recovery status of patients undergoing laparoscopic cholecystectomy Effect of premedication with oral clonidine on hemodynamics and recovery status of patients undergoing laparoscopic cholecystectomy 2020-01-21 anticipated 120 Complete https://irct.ir/trial/45255 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: In this study we use balanced randomization that at first four blocks with 9 combination will be formed and blocks will be numbered from 1to9. Compared to the simple randomization method, in this method the size of equilibrium of intervention and placebo groups will be established both during and at the end of study(randomization method is pre and post accidental blocks and will be done by randlist software), Blinding description: The anesthesiologist who has responsible for the patients management of anesthesia will administer the medicine(s) via coded syringes had been prepared previously and will not aware of the injected drug(clonidine or placebo ), and anesthesia nurse who is responsible for collection of patients information and study variables and is unaware of the administered drug will record the check- list during surgery and in the recovery.Also the patient is unaware of the injected medicine. 3 The effect of oral clonidine on hemodynamic status and recovery after cholecystectomy surgery.. Intervention 1: Intervention group: The patients of this group will receive 0.2 mg clonidine orally with water . Intervention 2: Control group: this group will receive placebo similar to intervention group. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is no further information