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IRCT20200122046221N1 IRCT 2020-05-11 Jahrom University of Medical Sciences The efficacy and side effects of oxytocin, methyl ergonovine (metergin) and misoprostol in the excretion of pregnancy products. Comparison of the efficacy and side effects of oxytocin + misoprostol with methyl ergonovine (metergin) + misoprostol and misoprostol alone in the excretion of pregnancy products. 2020-04-02 anticipated 90 Complete https://irct.ir/trial/45240 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Diagnostic, Randomization description: In this study, simple randomization method will be used, the randomization unit will be individualized and we will use random number table method to generate random sequence.People are divided into three groups (two case and one control group) . They also pack medication based on codes and another person who is unaware of the randomization process gives the drugs to the patients according to the mentioned codes .This randomization and allocation will be remained hidden from researchers and participants until the statistical analysis is completed, Blinding description: despite obtaining written consent from patients to participate in the study, they only knew that they would participate in the study to find the best way to get rid of pregnancy products after first trimester abortion, but they did not know which group of drugs was included in the drug coding (one-way blinding).the ampoules and tablets were presented to the researchers in similar syringes and covers respectively (with special codes ) so that it could not be identified for the researchers. Accordingly, the researchers who assisted patients in prescribing the drug, although they knew what the drug's content was in each package, were unaware of the research hypotheses, so they did not know which intervention group and which control group to use , It should be noted that the participants in each group were unaware of the drug regime of the opposite group.(double-blinding). And because the drugs were prescribed to patients with a coding system, the researcher did not know when the data was analyzed until the final calculations were performed. Because the researcher knew about the coding system and the researchers did not know about this system, but the data reached the researcher with numbers 1, 2 and 3, so the researcher did not know until the end of the analysis and before generalizing the calculations to the groups that the numbers one and Two or three belong to which codes A, B and C. It is obvious that the researcher's help wrote down the numbers belonging to the codes somewhere and gave them to the researcher after analyzing the data. In this research, three-way blinding technique was found. Coding system: control group: a, second group: b, third group: c (when delivering drug envelopes coded by the researcher with the help of the researcher) Group naming system with numbers: control group: 1, second group: 2, third group: 3 (when delivering data on therapeutic effects and side effects by the researcher to the researcher) Note: Research Assistant for Researcher after Data Analysis: Control Group: A-1, Second Group: B-2, Third Group C-3. 3 incomplete abortion in first trimester. Intervention 1: Intervention group: How to prescribe the drugs in the first intervention group: Oxytocin 1 amp (dose of amp: 10 unit) in the morning, 1 amp in the afternoon and 1 amp in the evening(IM injection) + misoprostol at a dose of 200 mg every 6 hours up to 3 days.An ultrasound is then performed to examine the remaining tissue And if the products are not passed, this diet will be repeated for another two periods. Intervention 2: Intervention group: How to administer the drugs in the second intervention group:1 amp metergin every 8 hour IM and tab misoprostol at a dose of 200 mg every 6 hours up to 3 days.An ultrasound is then performed to examine the remaining tissue And if the products are not passed, this diet will be repeated for another two periods. Intervention 3: Control group: This group will only receive Misoprostol 200mg sublingual tablets every 6 hours up to 3 days.An ultrasound is then performed to examine the remaining tissue And if the products are not passed, this diet will be repeated for another two periods. Yes - There is a plan to make this available What will be shared: data would be presented according to the jahrom university of medical sciences protocols When: according to the jahrom university of medical sciences protocols To whom: according to the jahrom university of medical sciences protocols Conditions: according to the jahrom university of medical sciences protocols Where to obtain: jahrom university of medical sciences How to obtain: according to the jahrom university of medical sciences protocols Comments:
public athar rasekhjahromi
Jahrom-Ostad Motahari Street-After School of Nursing-Jahrom University of Medical Sciences-Pardis site.
jahrom Iran (Islamic Republic of) ۷۴۱۴۸-۴۶۱۹۹ +98 71 5433 1521 drrasekh@yahoo.com Jahrom University of Medical Sciences scientific athar rasekhjahromi
Jahrom-Ostad Motahari Street-After School of Nursing-Jahrom University of Medical Sciences-Pardis site.
jahrom Iran (Islamic Republic of) ۷۴۱۴۸-۴۶۱۹۹ +98 71 5433 1521 drrasekh@yahoo.com Jahrom University of Medical Sciences Iran (Islamic Republic of) tendency toward outpatient treatment gestational age less than 14 week not presence of high risk disease 18 years 45 years Female presence of a major disease the patients who can not tolerate drugs those who get tired from the process of treatment O03.4 Incomplete spontaneous abortion without complication Diagnosis Diagnosis Diagnosis Intervention group: How to prescribe the drugs in the first intervention group: Oxytocin 1 amp (dose of amp: 10 unit) in the morning, 1 amp in the afternoon and 1 amp in the evening(IM injection) + misoprostol at a dose of 200 mg every 6 hours up to 3 days.An ultrasound is then performed to examine the remaining tissue And if the products are not passed, this diet will be repeated for another two periods. Intervention group: How to administer the drugs in the second intervention group:1 amp metergin every 8 hour IM and tab misoprostol at a dose of 200 mg every 6 hours up to 3 days.An ultrasound is then performed to examine the remaining tissue And if the products are not passed, this diet will be repeated for another two periods. Control group: This group will only receive Misoprostol 200mg sublingual tablets every 6 hours up to 3 days.An ultrasound is then performed to examine the remaining tissue And if the products are not passed, this diet will be repeated for another two periods Time of disposal of pregnancy products. Timepoint: Before starting the study . 3-6-9 days after starting the drug regimen. Method of measurement: The time from partial abortion to complete disposal of pregnancy products was measured. Jahrom University of Medical Sciences Approved 2017-06-03 jahrom university of medical science ethic comitte jahrom,motahari street,jahrom university of medical science jahrom Fars Iran (Islamic Republic of)