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IRCT20200119046187N1 IRCT 2020-04-11 Shahid Beheshti University of Medical Sciences Laser in lichen planus Evaluating the efficacy of the Er-Cr-YSGG laser before topical corticosteroid therapy in treatment of Oral lichen planus 2019-11-09 anticipated 40 Complete https://irct.ir/trial/45120 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: For treatment, symmetrical two focal lesions in the mouth are randomly divided into two groups. Accidental lesions are divided into two groups by permuted random block method as block 4, Blinding description: 1. The efficacy of laser is performed by a person other than the collector of the lesion information. 2. The person who is collecting the lesions information does not know in 3. For treatment, symmetrical two focal lesions in the mouth are randomly divided into two groups. Accidental lesions are divided into two groups by permuted random block method as block 4. 4. To blind the patient, a placebo laser is used on the opposite side. 3 Oral lichen planus. Intervention 1: Intervention group:Before starting drug treatment, this group is under laser radiation (Er.Cr.YSGG) with the specifications of the American Waterlase device (with 2780 nm parameters, energy: J / cm3 1.75, non-contact pattern, very long pulse, water: 70%, 80%: air, tip MZ 8, distance 1 mm, time 350 microseconds and this radiation is repeated 8 times in each session of visit in 8 consecutive weeks and at the same time using topical treatment Triamcinolone None ointment is applied for a maximum of 8 weeks, so that the entire surface of the lesion is covered by the above ointment three times a day after meals. Intervention 2: Control group: Topical treatments are treated with Trimcinolone NN ointment for a maximum of 8 weeks. In such a way that the whole surface of the lesion is smeared with the above ointment three times a day after eating and by the applicator.To blind the patient, a placebo laser is used on the opposite side. Yes - There is a plan to make this available What will be shared: There are currently plans to release the data. When: There are currently plans to release the data. To whom: There are currently plans to release the data. Conditions: There are currently plans to release the data. Where to obtain: There are currently plans to release the data. How to obtain: There are currently plans to release the data. Comments:
public Hamidreza khalighi
Department of Oral Medicine, Shahid Beheshti Dental School, Daneshjoo Boulevard, Evin, Shahid Chamran Highway, Tehran
Tehran Iran (Islamic Republic of) 1983969411 +98 21 2990 2302 dr.hkh92@gmail.com Shahid Beheshti University of Medical Sciences scientific Gelareh Forouzani
Department of Oral Medicine, Shahid Beheshti Dental School, Daneshjoo Boulevard, Evin, Shahid Chamran Highway, Tehran
Tehran Iran (Islamic Republic of) 19839369411 +98 21 2266 5704 glareh.forouzani@yahoo.com Shahid Beheshti University of Medical Sciences Iran (Islamic Republic of) Lichen planus Patients with symmetrical two focal parts Patient satisfaction and cooperation no limit no limit Both Recurrence history Mucocutaneous involvement Take effective medications over the past month The history of the cancer in the head and neck History of proliferative diseases History of thyroid disease Pregnancy Keratotic lichen planus L43 Lichen planus Treatment - Drugs Placebo Intervention group:Before starting drug treatment, this group is under laser radiation (Er.Cr.YSGG) with the specifications of the American Waterlase device (with 2780 nm parameters, energy: J / cm3 1.75, non-contact pattern, very long pulse, water: 70%, 80%: air, tip MZ 8, distance 1 mm, time 350 microseconds and this radiation is repeated 8 times in each session of visit in 8 consecutive weeks and at the same time using topical treatment Triamcinolone None ointment is applied for a maximum of 8 weeks, so that the entire surface of the lesion is covered by the above ointment three times a day after meals. Control group: Topical treatments are treated with Trimcinolone NN ointment for a maximum of 8 weeks. In such a way that the whole surface of the lesion is smeared with the above ointment three times a day after eating and by the applicator.To blind the patient, a placebo laser is used on the opposite side. Oral lichen planus lesions recovery time:time to reach score 1 or zero according to Thongprasom sign scoring in weeks 1 to 8. According to Thongprasom sign scoring in oral lichen planus lesion the score is from zero to five. Zero score: no wounds - Natural mucus, score 1: mild white steria , score 2: white steria with atrophic and erythematous areas (less than 1 cm square), score 3: white steria with atrophic and erythematous areas (more than 1 cm square), score 4: White steria with ulcerative (less than 1 cm square), score 5: White steria with ulcerative (more than 1 cm square). Timepoint: In each session before treatment, 8 times in 8 consecutive weeks. Method of measurement: By collis and clinical observation. The severity of the lesion is based on Thongprasom sign scoring (categories 0 to 5). Timepoint: In each session before treatment, 8 times in 8 consecutive weeks. Method of measurement: By the collis and clinical observation in each session before the start of treatment in mm / cm (categories 0 to 5). Burning intensity: Verbal Analog scale (score 0 to 10):The patient's severity of discomfort from the burning for each lesion is measured separately by the analog scale verbal criteria, so that the number zero is considered as non-irritating and the number ten is considered as the highest possible burn and the patient is asked to number In this interval, select as the intensity of the burn. Timepoint: In each session before treatment, 8 times in 8 consecutive weeks. Method of measurement: By determining the number by patients in each session before starting treatment. Shahid beheshti University of medical science, dental school Approved 2019-10-08 Ethics committee of Shahid beheshti University of Medical Sciences Department of Oral Medicine, Shahid Beheshti Dental School, Daneshjoo Boulevard, Evin, Shahid Chamran Highway, Tehran Tehran Tehran Iran (Islamic Republic of)