IRCT20191231045968N1 IRCT 2020-07-20 Kharazmi University The effect of curcumin supplementation plus resistance training in treatment of patients with Parkinson's Clinical trial of the effect of curcumin supplementation plus resistance training compared with the placebo on disease severity and metabolic profiles in patients with Parkinson's 2020-06-06 anticipated 40 Complete https://irct.ir/trial/45058 interventional Randomization: Randomized, Blinding: Not blinded, Placebo: Used, Assignment: Factorial, Purpose: Supportive, Other design features: The patients and researchers have direct connection in order to performing the exercises thus, this study is not blinded. This work is a open labeled study, Randomization description: At study baseline, participants based on balanced blocked randomization will be allocated into four groups to take either curcumin supplementation plus resistance training (n=10), curcumin supplementation (n = 10), resistance training (n=10) or placebo (n = 10). Randomization will be done by the use of computer-generated random numbers. 3 Parkinson disease. Intervention 1: 500 mg curcumin capsule ( contain 450 mg turmeric powder and 50 mg tumeric concentration equivalent with 47.5 mg curcumin) twice a day, for 8 weeks. Exercises are designed in format of 3 circles in each session. The main exercise will be designed with variable intensity suitable with person's ability. The equipment includes leg extension and flexion machine, under hand cable pull down, chest press, shoulder press, elbow extension and flexion machine. The exercises are designed for 3 times per week ( 60 min for each time) for 8 weeks. Intervention 2: Intervention group: Resistance training (three times a week) for 8 weeks. Intervention 3: Intervention group: 500 mg curcumin capsule twice a day plus resistance training (three times a week) for 8 weeks. Intervention 4: Control group: Without resistance training and the consumption of curcumin supplementation. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is هنوز تصمیم نگرفته‌ام - برنامه انتشار آن هنوز مشخص نیست