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IRCT20100412003690N11 IRCT 2020-02-06 Tabriz University of Medical Sciences Evaluation of Alvora Gel in Inflammatory Factors in Patients with Periodontitis The Effect of Topical Application of Aloe Vera Gel on IL-1B, IL-17 of Crevicular Fluid in patients with chronic Periodontitis 2020-02-20 anticipated 34 Complete https://irct.ir/trial/44975 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: The patients will be randomly divided into two intervention groups using dice throwing and even and odd numbers. The intervention group will be the odd numbers and the control group will be even numbers, Blinding description: All measurements will be performed by an examiner who is blind to the type of treatment. 4 Periodontitis. Intervention 1: Intervention group:Aloe vera gel will be injected into the periodontal envelope using an insulin syringe so that the gel enters and fills up to the apical envelope and the gel exits the gingival margin. Intervention 2: Control group: Distilled water will be injected into the periodontal envelope using an insulin syringe so that the water enters and fills up to the apical envelope and exits the gingival margin. Yes - There is a plan to make this available What will be shared: The data obtained from the participants can be presented in the form of a table. The protocol for the study, which is routine methods, has no problems with its publication. Statistical analysis can also be provided. In this study, an informed consent form will be used that can be published without mentioning the person's name and personal details. A clinical study report can be made after the necessary analyzes. When: Start the access period 9 months after publishing the results To whom: For researchers in Dental school of Tabriz University Conditions: For scholars working in other academic and academic institutions, if approved by the project implementer Where to obtain: Dr. Masoomeh Faramarzi, email or phone Dental school of Tabriz University, Periodontics department, 9144113420 0098 ، faramarzim@tbzmed.ac.ir How to obtain: After receiving the request will be answered within a week. Comments:
public Masoomeh Faramarzi
Faculty of Dentistry, Tabriz University of Medical Sciences, Golgasht Ave, Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 1385 4863 ّFaramarzim@tbzmed.ac.ir Tabriz University of Medical Sciences scientific Masoomeh Faramarzi
Faculty of Dentistry, Tabriz University of Medical Sciences, Golgasht Ave, Tabriz, Iran
Tabriz Iran (Islamic Republic of) 5166614711 +98 41 1385 4863 Faramarzim@tbzmed.ac.ir Tabriz University of Medical Sciences Iran (Islamic Republic of) Moderate to severe زchronic periodontitis Age 35-50 Have at least 4 teeth with probe depth of 4 mm or more in each jaw quadrant Consent to participate in the study Patients candidate for non-surgical treatment 35 years 50 years Both Allergy to aloe vera or its products Use of tobacco Endodontic and periodontal compound lesions Periapical lesions Pregnancy Severe dental caries Semi-impacted teeth Orthodontic patients Systemic diseases and systemic or topical antibiotic users 6 Months befor study Patients with periodontal disease during the past 6 months and patients receiving periodontal treatment 6 months before study Patients receiving NSAIDs one month before sampling K05.3 Chronic periodontitis Treatment - Drugs Placebo Intervention group:Aloe vera gel will be injected into the periodontal envelope using an insulin syringe so that the gel enters and fills up to the apical envelope and the gel exits the gingival margin. Control group: Distilled water will be injected into the periodontal envelope using an insulin syringe so that the water enters and fills up to the apical envelope and exits the gingival margin. Plaque Index (PI). Timepoint: Before entrance in the study and 30 days after initial treatment. Method of measurement: Using the index (O'Leary 1972). Gingival Index (GI). Timepoint: Before entrance in the study and 30 days after initial treatment. Method of measurement: According to the Loe & Sillness Index. Probe depth (PD). Timepoint: Before entrance in the study and 30 days after initial treatment. Method of measurement: Using Williams probe 6 levels of teeth. IL-1B. Timepoint: Before entrance in the study and 30 days after initial treatment. Method of measurement: Using ELISA kit. IL-17. Timepoint: Before entrance in the study and 30 days after initial treatment. Method of measurement: Using ELISA kit. Tabriz University of Medical Sciences Approved 2020-01-06 Ethics committee of Tabriz University of Medical Sciences International Relations Office, No 2 Central Building, Tabriz University of Medical Sciences, University Street, Tabriz Tabriz East Azarbaijan Iran (Islamic Republic of)