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IRCT20180613040087N2 IRCT 2020-02-22 Shiraz University of Medical Sciences Epinephrine administration during cardiopulmonary resuscitation CPR (cardiopulmonary resuscitation) Comparison of the Effectiveness of Central versus Peripheral Administration of Epinephrine in Success of Return of Spontaneous Circulation in Cardiopulmonary Arrest Patients 2019-02-20 anticipated 8 Complete https://irct.ir/trial/44856 interventional Randomization: Not randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Other design features: All patients will be immediately resuscitated based on AHA guidelines. All patients will have central or peripheral line before resuscitation. Trained PGY-2 and PGY-3 emergency medicine residents will be the leader of CPR. Sample size is estimated based on the census subjects in each group, Blinding description: Outcome assessors are blinded to treatment allocation. The one who record the data is blinded to the type of interventions and the investigators doing the analysis are not the same as those administering drug and performing the procedures. 3 Cardiopulmonary Arrest. Intervention 1: Control group: Patients in the group one will be administered 1 mg Epinephrine every 3-5 minutes through peripheral venous during CPR. All the patients will have peripheral line before resuscitation. Intervention 2: Intervention group:The patients in the group two will be received 1 mg Epinephrine every 3-5 minutes administering through central venous. All the patients will have central line before resuscitation. Yes - There is a plan to make this available What will be shared: All data related to the patients will be shared after identifying the patients When: Starting 1 month after publication To whom: This only available for people working in academic institutions Conditions: All statistical analysis are allowed in line with the objectives of the study. Application terms for access to data including: People working in academic institutions who have registered a protocol liked our study. People are committed to data protection Where to obtain: Azadeh Tafakori, Shiraz Nemazee Hospital, Email: dr.azadeh.tafakori@gmail.com How to obtain: Through automation correspondence or email Comments:
public Babak Bagheri
Emergency Medicine Department, Namazi hospital, Zand Ave
Shiraz Iran (Islamic Republic of) 7193613311 +98 71 3647 4952 babakbagheri86@yahoo.com Shiraz University of Medical Sciences scientific Azadeh Tafakori
Emergency Medicine Department, Namazi hospital, Zand Ave
Shiraz Iran (Islamic Republic of) 7193613311 +98 71 3647 4952 dr.azadeh.tafakori@gmail.com Shiraz University of Medical Sciences Iran (Islamic Republic of) Adult patients with cardiopulmonary arrest admitted to the emergency department of Namazi hospital 18 years no limit Both Patients with age less than 18 years old All patients with GCS = 3 before CPR All patients expired before CPR I46 Cardiac arrest Treatment - Drugs Treatment - Drugs Control group: Patients in the group one will be administered 1 mg Epinephrine every 3-5 minutes through peripheral venous during CPR. All the patients will have peripheral line before resuscitation. Intervention group:The patients in the group two will be received 1 mg Epinephrine every 3-5 minutes administering through central venous. All the patients will have central line before resuscitation. Systolic and diastolic blood pressure. Timepoint: After return of spontaneous circulation. Method of measurement: Sphygmomonometer. Heart rate. Timepoint: After return of spontaneous circulation. Method of measurement: Chronometer. Elapsed time to return of spontaneous circulation. Timepoint: After return of spontaneous circulation. Method of measurement: Chronometer. Success rate of return of spontaneous circulation. Timepoint: After return of spontaneous circulation. Method of measurement: Monitor and pulse checking. Mortality rate. Timepoint: After return of spontaneous circulation. Method of measurement: Monitor and pulse checking. Shiraz University of Medical Sciences Approved 2019-02-19 Ethics committee of Shiraz Univesity of Medical Sciences Headquarters of Shiraz Univesity of Medical Sciences, Zand St, Shiraz Shiraz Fars Iran (Islamic Republic of)