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IRCT20200107046033N1 IRCT 2020-02-23 Sabzevar University of Medical Sciences effect of Harpagophytum and Curcuma and diclofenac sodium in elderly patients with osteoarthritis The comparison of the effect of Harpagophytum and Curcuma and diclofenac sodium on pain, stiffness and physical function of knee in elderly patients with osteoarthritis 2020-04-03 anticipated 60 Complete https://irct.ir/trial/44836 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Individuals who were eligible for the study were randomly assigned to the six-group permutation blog (blocks are multiples of the number of groups) with 6 individuals divided into three groups. Random number tables are used to select the number of blocks. (Permuted block randomization (6 parts), Blinding description: Participant blindness: The drugs in the study are placed in identical containers and provided by the researcher with the help of the participant. Researcher blindness: Benefiting from researcher assistance. 3 osteoarthritis. Intervention 1: Intervention group 1: 40 mg curcumin tablet administered by Exir Nano Sina Pharmaceutical Company once daily. Intervention 2: Intervention group 2: Talental 480 mg tablet administered by Razak Pharmaceutical Company twice daily. Intervention 3: Intervention group III: 25mg sodium diclofenac tablet administered by Razak Pharmaceutical Company twice daily. Yes - There is a plan to make this available What will be shared: Information about the results of the study can be published. When: Data Access: Six months after the article was published To whom: Researchers working in academic and scientific institutions Industry practitioners Traditional medicine centers Conditions: Researchers can provide their clients with a range of seniority and therapies as written research requests with the consent of their international company. Where to obtain: After obtaining the written consent of the research team, it is possible to refer or correspond to the Vice President of Research and Technology of Sabzevar University of Medical Sciences. How to obtain: After obtaining the written consent of the research team, it is possible to refer or correspond to the Vice President of Research and Technology of Sabzevar University of Medical Sciences. Comments:
public Raha Salehabadi
Sabzevar university of medical sciences
savzevar Iran (Islamic Republic of) 9618755736 +98 51 4401 8314 rahasalehabadi@gmail.com Sabzevar University of Medical Sciences scientific Fereshte Ghorat
Vice-chancellor in Research and Technology, Sabzevar University of Medical Sciences, Sabzevar, POBox 319, Iran
Sabzevar Iran (Islamic Republic of) 9618755736 +98 51 4401 8319 ghorat@gmail.com Sabzevar University of Medical Sciences Iran (Islamic Republic of) Knee osteoarthritis diagnosed by radiographic evidence and medical expert Knee pain more than two months Acceptable cognitive ability based on a brief cognitive test tool (score of 7 and above) No history of surgery related to the disease (eg replacement and joint repair) Non-injection of the drug into the knee joint within 30 days prior to intervention or schedule for injection until the end Study period 60 years no limit Both Taking narcotic drugs History of gallbladder and liver disease any surgery in the next 2 weeks Blindness and deafness and inability to communicate severe and untreated diseases Use of psychotropic drugs Treatment - Drugs Treatment - Drugs Treatment - Drugs Intervention group 1: 40 mg curcumin tablet administered by Exir Nano Sina Pharmaceutical Company once daily. Intervention group 2: Talental 480 mg tablet administered by Razak Pharmaceutical Company twice daily. Intervention group III: 25mg sodium diclofenac tablet administered by Razak Pharmaceutical Company twice daily. Pain, stiffness and knee joint function based on the WOMAC questionnaire. Timepoint: In 5 steps at the beginning of the experiment and at intervals of one week to one month. Method of measurement: WOMAC questionnaire. Pain reduction. Timepoint: 5 times: 1 before intervention and 4 times after intervention with weekly intervals for 4 weeks. Method of measurement: WOMAC questionnaire. Bojnord University of Medical Sciences Approved 2020-01-04 Ethics committee of Sabzevar University of Medical Sciences Hemmat5- Adib2- niyayesh Sabzevar Razavi Khorasan Iran (Islamic Republic of)