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IRCT20191222045847N1 IRCT 2020-02-11 Tehran University of Medical Sciences comparison effects of two regimens: prednisolone plus cimetidine versus prednisolone plus colchicine in control of frequency and duration of fever episodes In the Periodic fever, Aphthous stomatitis, Pharyngitis and Adenitis in children referred to pediatric medical center comparison effects of two regimens: prednisolone plus cimetidine versus prednisolone plus colchicine in control of frequency and duration of fever episodes In the Periodic fever, Aphthous stomatitis, Pharyngitis and Adenitis in children referred to pediatric medical center 2019-10-23 anticipated 80 Complete https://irct.ir/trial/44778 interventional Randomization: Randomized, Blinding: Triple blinded, Placebo: Not used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization(given a block size of 4), Blinding description: The participant, the researcher, the clinical supervisor and the analyzer are not aware of the intended drug intervention. 2-3 PFAPA syndrome. Intervention 1: Intervention group: PFAPA syndrome patients treated with prednisolone and cimetidine. Intervention 2: Intervention group: PFAPA syndrome patients treated with prednisolone and colchicin. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is No more information
public Mahdieh Vahedi
Azadi st, Qanei Alley,No 10.
Tehran Iran (Islamic Republic of) 1457966768 +98 21 6692 8051 mahvahedi_62@yahoo.com Tehran University of Medical Sciences scientific Mahdieh Vahedi
Azadi st, Qanei Alley,No 10.
Tehran Iran (Islamic Republic of) 1457966768 +98 21 6692 8051 mahvahedi_62@yahoo.com Tehran University of Medical Sciences Iran (Islamic Republic of) Iran (Islamic Republic of) 1. Age of onset of symptoms from 1 year to 10 years of age 2. Absence of inflammatory or other rheumatic disease at the same time 3.there are No concomitant disease that this drugs contraindicated on it (prednisolone, cimetidine, colchicine). 1 year 10 years Both Treatment - Drugs Treatment - Drugs Intervention group: PFAPA syndrome patients treated with prednisolone and cimetidine Intervention group: PFAPA syndrome patients treated with prednisolone and colchicin Frequency and duration of fever episodes in PFAPA. Timepoint: Before starting the study and 3 months later. Method of measurement: questionnaire. Tehran University of Medical Sciences Approved 2019-10-23 Ethics committee of school of medicine-Tehran university of medical science Deputy of Education, Seventh Floor, Central Organization of Tehran University of Medical Sciences, Qods Ave., Keshavarz Blvd., Tehran, Iran tehran Tehran Iran (Islamic Republic of)