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IRCT20191229045935N1 IRCT 2020-03-04 Kashan University of Medical Sciences The effect of two different doses of the drug on hemodynamic responses in patients undergoing laparoscopic cholecystectomy Comparison study of two doses of magnesium sulfate on hemodynamic response to endotracheal intubation in laparoscopic cholecystectomy 2019-02-27 anticipated 60 Complete https://irct.ir/trial/44676 interventional Randomization: Randomized, Blinding: Single blinded, Placebo: Not used, Assignment: Parallel, Purpose: Prevention, Randomization description: Patients III-IASA were candidates for elective laparoscopic elective cholecystectomy at Shahid Beheshti Hospital in Kashan after obtaining written consent random blocks with 6 blocks are divided into 3 groups. In the case of central hiding randomization, in this method, the random sequence is assigned to a particular person or center and sampling is performed at one or more centers simultaneously. Based on the order of the participants' entry into the study, the researcher communicates with the relevant center and asks about the random assignment of the participant to a specific group, Blinding description: Patients from two different doses of magnesium sulfate are completely blind to their hemodynamic responses. 0 (exploratory trials) Patients undergoing CABG. Intervention 1: Intervention group: Magnesium sulfate 30mg / kg infusion within 5 minutes which continues before induction. The studied drugs were manufactured by Judge Tabriz Company from Alborz Broadcasting Company and recorded at the time of tracheal intubation, 2, 4, 6 and 10 minutes after tracheal intubation.nd 10 minutes after tracheal intubation. Intervention 2: Intervention group: Magnesium sulfate 40mg / kg is infused for 5 minutes and continues until induction. The studied drugs were manufactured by Judge Tabriz Company from Alborz Broadcasting Company and recorded at the time of tracheal intubation, 2, 4, 6 and 10 minutes after tracheal intubation. Intervention 3: Control group: Normal saline equal to the intervention group as placebo, which is infused like the other two groups within 5 minutes and will continue until induction.The studied drugs were manufactured by Judge Tabriz Company from Alborz Broadcasting Company and recorded at the time of tracheal intubation, 2, 4, 6 and 10 minutes after tracheal intubation. Yes - There is a plan to make this available What will be shared: Some portion of the dose information can be shared. When: Starting access after printing the article. To whom: All researchers Conditions: For use in surgeries Where to obtain: Author corresponding How to obtain: An in-person or written request by email Comments:
public Jafar Kazemeini
Kashan university of medical sciences, Qotbe Ravandi Blvd, Kashan
Kashan Iran (Islamic Republic of) 8711111111 +98 31 5550 0111 kazemeini-j@mail.kaums.ac.ir Kashan University of Medical Sciences scientific Jafar Kazemaini
Kashan university of medical sciences, Qotbe Ravandi Blvd, Kashan
Kashan Iran (Islamic Republic of) 8711111111 +98 31 5550 0111 kazemeini-j@mail.kaums.ac.ir Iran University of Medical Sciences Iran (Islamic Republic of) ASA II-III Patients Candidate for Laparoscopic Elective Cholecystectomy 18 years 75 years Both Emergency Surgery Probability of intubation problem Sensitivity to magnesium sulfate Cardiac arrhythmia Serum creatinine above 2 mg / dl pregnant women Patients with severe heart valve disorders Patients with aortic stenosis Treatment - Drugs Treatment - Drugs Placebo Intervention group: Magnesium sulfate 30mg / kg infusion within 5 minutes which continues before induction. The studied drugs were manufactured by Judge Tabriz Company from Alborz Broadcasting Company and recorded at the time of tracheal intubation, 2, 4, 6 and 10 minutes after tracheal intubation.nd 10 minutes after tracheal intubation. Intervention group: Magnesium sulfate 40mg / kg is infused for 5 minutes and continues until induction. The studied drugs were manufactured by Judge Tabriz Company from Alborz Broadcasting Company and recorded at the time of tracheal intubation, 2, 4, 6 and 10 minutes after tracheal intubation. Control group: Normal saline equal to the intervention group as placebo, which is infused like the other two groups within 5 minutes and will continue until induction.The studied drugs were manufactured by Judge Tabriz Company from Alborz Broadcasting Company and recorded at the time of tracheal intubation, 2, 4, 6 and 10 minutes after tracheal intubation. Heart rate. Timepoint: At the time of tracheal, and 2, 4, 6, and 10 minutes after tracheal intubation. Method of measurement: Digital barometer. Systolic blood pressure, diastolic blood pressure, and mean blood pressure. Timepoint: systolic blood pressure, diastolic blood pressure, and mean blood pressure before infusion to induction were recorded at different time points, including anesthesia induction, at the time of tracheal, and 2, 4, 6, and 10 minutes after tracheal intubation. Method of measurement: Mercury barometer. Kashan University of Medical Sciences Approved 2019-02-12 Kashan university of medical sciences, Qotbe Ravandi Blvd, Kashan Kashan university of medical sciences, Qotbe Ravandi Blvd, Kashan Kashan Isfehan Iran (Islamic Republic of)