IRCT20191220045829N1 IRCT 2021-09-27 Kashan University of Medical Sciences Comparison of the effect of dexmedetomidine and magnesium sulfate in patients undergoing laparoscopic cholecystectomy Comparison of the effect of dexmedetomidine and magnesium sulfate in controlling hemodynamic changes in patients undergoing laparoscopic cholecystectomy 2017-09-23 anticipated 75 Complete https://irct.ir/trial/44391 interventional Randomization: Randomized, Blinding: Double blinded, Placebo: Used, Assignment: Parallel, Purpose: Treatment, Randomization description: Block randomization was used to randomly assign people to three groups and to ensure that the number of people in groups is balanced. Participants randomly had been divided into three groups: dexmedomidine, magnesium sulfate, and control. One envelope was opened for each patient, each envelope had a random number. It had been predetermined that each random number belongs to one of the three groups mentioned, Blinding description: Participants consented to participate in the study but were unaware of which group they were in. The clinical caregiver recording the data was not aware of the type of patient group. 3 Laparoscopic cholecystectomy. Intervention 1: Intervention group: Dexmedetomidine 1µg/kg was injected intravenously in 20 ml normal saline for ten minutes before induction of anesthesia, and dexmedetomidine 0.5µg/kg per hour after induction of it. Intervention 2: Intervention group: Before induction of anesthesia, 4ml magnesium sulfate 50% (2gr) was infused in 20 ml normal saline for ten minutes and after induction of it, magnesium sulfate 50% (0.9mg/kg) was infused intravenously per hour. Intervention 3: Control group: Normal saline was injected intravenously in 20 ml volume for ten minutes before and after induction of anesthesia. Undecided - It is not yet known if there will be a plan to make this available Justification or reason for indecision in sharing IPD is There is not more information